Abstract:
:Stimulation of mast cells through their high affinity IgE receptor (FcεRI) leads to the secretion of pre- and neoformed soluble mediators through vesicular carriers. This process is highly regulated in order to adapt the secretion of these potentially dangerous factors to the physiological needs. This regulation requires numerous essential effectors that are necessary to transmit the initial signal of FcεRI aggregation and couple it to the sophisticated secretory machinery of membrane fusion. Studies in recent years have led to the discovery of a series of new effector molecules that link FcεRI to secretion. We describe here some of the new developments that have allowed to obtain a clearer picture of stimulus/secretion coupling in mast cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Benhamou M,Blank Udoi
10.1016/j.febslet.2010.09.023subject
Has Abstractpub_date
2010-12-15 00:00:00pages
4941-8issue
24eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00750-7journal_volume
584pub_type
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