Abstract:
:The crawling locomotion and shape of eukaryotic cells have been associated with the stochastic molecular dynamics of actin and its protein regulators, chiefly Arp2/3 and Rho family GTPases, in making a cytoskeleton meshwork within cell extensions. However, the cell's actin-dependent oscillatory shape and extension dynamics may also yield insights into locomotory mechanisms. Confocal observations of live Dictyostelium cells, expressing a green fluorescent protein-actin fusion protein, demonstrate oscillating supramolecular patterns of filamentous actin throughout the cell, which generate pseudopodia at the cell edge. The distinctively dissipative spatio-temporal behavior of these structures provides strong evidence that reversible actin filament assembly propagates as a self-organized, chemical reaction-diffusion wave.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Vicker MGdoi
10.1016/s0014-5793(01)03207-0keywords:
subject
Has Abstractpub_date
2002-01-02 00:00:00pages
5-9issue
1-2eissn
0014-5793issn
1873-3468pii
S0014579301032070journal_volume
510pub_type
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