Abstract:
:The aim of this study was to investigate the distribution of a calcium-inhibitable adenylyl cyclase type VI (type VI AC) in the central nervous system using an antiserum directed against the N-terminus of type VI AC. Our results indicate that type VI AC immunoreactivity is generally expressed in many brain regions with different levels of intensity. Most interestingly, the majority of the detected type VI AC immunoreactivity is present in cells of neuronal phenotype. Double immunostaining of type VI AC and markers of various neurotransmitter systems suggest that type VI AC might participate in regulation of the classical neurotransmitter systems and therefore appeared to play a very important role in the central nervous system.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Liu FC,Wu GC,Hsieh ST,Lai HL,Wang HF,Wang TW,Chern Ydoi
10.1016/s0014-5793(98)01098-9subject
Has Abstractpub_date
1998-09-25 00:00:00pages
92-8issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(98)01098-9journal_volume
436pub_type
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