当前位置： SCI文献检索 > FEBS LETTERS期刊下所有文献 > Bacterial lectins, cell-cell recognition and infectious disease.

Bacterial lectins, cell-cell recognition and infectious disease.

Abstract：

:Numerous bacterial strains produce surface lectins, commonly in the form of fimbriae that are filamentous assemblies of protein subunits. Among the best characterized of these are the type 1 (mannose specific) fimbrial lectins of Escherichia coli that consist almost exclusively of one class of subunit with a molecular mass of 17 kDa. They possess an extended combining site corresponding to a trisaccharide and preferentially bind carbohydrate units of oligomannose or hybrid type. Type 1 fimbriae also possess a hydrophobic region close to the carbohydrate-binding site, since aromatic alpha-mannosides inhibit strongly (up to 1000-times more than methyl alpha-mannoside) the agglutination of yeasts by the bacteria and the adherence of the latter to pig ileal epithelial cells. The combining sites of type 1 fimbriae of the salmonellae and of other enteric bacteria are different from those of E. coli in that they are smaller and do not possess a hydrophobic region. The various bacterial surface lectins appear to function primarily in the initiation of infection by mediating bacterial adherence to epithelial cells, e.g. in the urinary and gastrointestinal tracts. The mannose specific lectins also act as recognition molecules in lectinophagocytosis (i.e. phagocytosis of the bacteria in the absence of opsonins) by mouse, rat and human peritoneal macrophages, and human polymorphonuclear leukocytes. Affinity chromatography of membrane lysates from human polymorphonuclear leukocytes on immobilized type 1 fimbrial lectin, using methyl alpha-mannoside as eluent, showed that glycoproteins with apparent molecular masses of 70-80, 100 and 150 kDa act as receptors for the bacteria. Inhibition experiments with monoclonal antibodies suggest that the glycoprotein bands of 100 and 150 kDa may be identical with the alpha and beta subunits of leukocyte complement receptors and adhesion glycoproteins involved in complement-mediated opsonophagocytosis. The systems described serve as a fine illustration for the biological role of lectin-carbohydrate interactions. Further studies of these systems will lead to a deeper understanding of the molecular basis of infectious diseases, and perhaps also to new approaches for their prevention.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Sharon N

doi

10.1016/0014-5793(87)80654-3

subject

Has Abstract

pub_date

1987-06-15 00:00:00

pages

145-57

issue

2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(87)80654-3

journal_volume

217

pub_type

杂志文章,评审

相关文献

FEBS LETTERS文献大全
  • Potentiation of the antagonistic effect of ACTH11-24 on steroidogenesis by synthesis of covalent dimeric conjugates.

    abstract：:Covalent dimerization of the adrenocorticotropin fragment ACTH11-24 increases its antagonistic potency on the ACTH-induced steroidogenesis in isolated bovine fasciculata/reticularis cells by 3 orders of magnitude when the C-termini are linked via a 10 A long spacer. This strong potentiation, probably mediated by cross...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(85)80794-8

    authors： Fauchère JL,Rossier M,Capponi A,Vallotton MB

    更新日期：1985-04-22 00:00:00

  • The human homologue of the yeast mitochondrial AAA metalloprotease Yme1p complements a yeast yme1 disruptant.

    abstract：:In yeast, three AAA superfamily metalloproteases (Yme1p, Afg3p and Rca1p) are localized to the mitochondrial inner membrane where they perform roles in the assembly and turnover of the respiratory chain complexes. We have investigated the function of the proposed human orthologue of yeast Yme1p, encoded by the YME1L g...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/s0014-5793(00)01859-7

    authors： Shah ZH,Hakkaart GA,Arku B,de Jong L,van der Spek H,Grivell LA,Jacobs HT

    更新日期：2000-08-04 00:00:00

  • Heme incorporation into the cytochrome bo3 occurs at a late stage of assembly.

    abstract：:Respiratory complexes in both prokaryotes and eukaryotes contain multiple co-factors, which are coordinated in defined positions so that they can function as electron wires. Intriguingly, co-factors are usually buried deep within hetero-oligomeric protein complexes and it is not clear when or how they are incorporated...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/j.febslet.2012.10.021

    authors： Palombo I,Daley DO

    更新日期：2012-11-30 00:00:00

  • Expanded amino acid sequence of the PhaC box in the active center of polyhydroxyalkanoate synthases.

    abstract：:Polyhydroxyalkanoate (PHA) synthases catalyze the polymerization reaction of the acyl moiety of hydroxyacyl-coenzyme A into polyester. The catalytic subunit PhaC of PHA synthase has the PhaC box sequence at the active site that is typically described as G-X-C-X-G-G (X is an arbitrary amino acid), and cysteine is an ac...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1002/1873-3468.13651

    authors： Nambu Y,Ishii-Hyakutake M,Harada K,Mizuno S,Tsuge T

    更新日期：2020-02-01 00:00:00

  • Composition and immunological significance of the upper respiratory tract microbiota.

    abstract：:The intestinal microbiota is essential for nutrient acquisition, immune development, and exclusion of invading pathogens. The upper respiratory tract (URT) microbiota is less well studied and does not appear to abide by many of the paradigms of the gastrointestinal tract. Decades of carriage studies in children have d...

    journal_title：FEBS letters

    pub_type： 杂志文章,评审

    doi：10.1002/1873-3468.12455

    authors： Schenck LP,Surette MG,Bowdish DM

    更新日期：2016-11-01 00:00:00

  • A mutation affecting carbon catabolite repression suppresses growth defects in pyruvate carboxylase mutants from Saccharomyces cerevisiae.

    abstract：:Yeasts with disruptions in the genes PYC1 and PYC2 encoding the isoenzymes of pyruvate carboxylase cannot grow in a glucose-ammonium medium (Stucka et al. (1991) Mol. Gen. Genet. 229, 307-315). We have isolated a dominant mutation, BPC1-1, that allows growth in this medium of yeasts with interrupted PYC1 and PYC2 gene...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(95)01337-7

    authors： Blázquez MA,Gamo FJ,Gancedo C

    更新日期：1995-12-18 00:00:00

  • Interpretation of the reactivity of peroxidase compounds I and II with phenols by the Marcus equation.

    abstract：:The catalytic cycle of heme peroxidases involves two reactive states, compound I and compound II. Although their reduction potentials at pH 7 are similar, compound I is in general more reactive towards organic substrates than compound II. The different reactivities have until now remained unexplained. In this study, t...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/s0014-5793(97)00792-8

    authors： Folkes LK,Candeias LP

    更新日期：1997-07-28 00:00:00

  • Location of two of the introns in the antithrombin-III gene.

    abstract：:At least two of the introns in the antithrombin-III (AT-III) gene are located in positions different from those of the other three proteins in this superfamily for which the gene structures are known, namely, ovalbumin, alpha 1-antitrypsin and angiotensinogen. In another part of the 3'-portion of the AT-III gene there...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(85)80154-x

    authors： Jagd S,Vibe-Pedersen K,Magnusson S

    更新日期：1985-12-02 00:00:00

  • Saccharomyces cerevisiae mRNA populations of different intrinsic stability in unstressed and heat shocked cells display almost constant m7GpppA:m7GpppG 5'-cap structure ratios.

    abstract：:The half-lives of mRNAs in yeast vary from about 1 to over 100 min. While mRNA stabilities must strongly influence overall gene expression in this organism, very little is known about how they are determined. Labellings of yeast cells were conducted to investigate whether the 5'-cap structures of yeast mRNAs might inf...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(87)80898-0

    authors： Piper PW,Curran B,Davies W,Hirst K,Seward K

    更新日期：1987-08-10 00:00:00

  • Identification of a 42 kDa protein as a substrate of protein phosphatase 1 in cilia from Paramecium.

    abstract：:Okadaic acid, a specific inhibitor of protein phosphatase 1 in Paramecium causes sustained backward swimming in response to depolarising stimuli (S. Klumpp et al. (1990) EMBO J. 9, 685). Here, we employ okadaic acid, tautomycin, microcystin LR and inhibitor 1 as phosphatase inhibitors to identify a 42 kDa protein in t...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(91)81003-q

    authors： Klumpp S,Schultz JE

    更新日期：1991-08-19 00:00:00

  • Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.

    abstract：:Lysophosphatidic acid (LPA) exerts multiple biological functions through G protein-coupled receptors (EDG2/LPA(1), EDG4/LPA(2), and EDG7/LPA(3)) and is present in serum where it is associated with albumin. In this study we examined LPA activity in various biological fluids by measuring the LPA-induced increase in the ...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/s0014-5793(02)02976-9

    authors： Hama K,Bandoh K,Kakehi Y,Aoki J,Arai H

    更新日期：2002-07-17 00:00:00

  • Regulation of fructose 2,6-bisphosphate levels in cold-acclimated brown adipose tissue of rat.

    abstract：:The effects of cold exposure and T4 administration on fructose 2,6-bisphosphate levels, phosphofructokinase-2 and pyruvate kinase activities were examined in rat brown adipose tissue. Cold adaptation (14 days) gave rise to a 2-fold increase in the amount of fructose 2,6-bisphosphate and phosphofructokinase-2 activity,...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(88)80804-4

    authors： Sobrino F,Gualberto A,Pintado E

    更新日期：1988-02-29 00:00:00

  • Sequence analysis of the cloned streptococcal cell surface antigen I/II.

    abstract：:The gene spa P (formerly designated as spa P1) encoding the Mr 185,000 surface antigen (I/II) of Streptococcus mutans, serotype c (NG5), has been sequenced. The gene (4683 bp) encodes a protein of 1561 amino acid residues including putative signal peptide (residues 1-38) and transmembrane (residues 1537-1556) sequence...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(89)81632-1

    authors： Kelly C,Evans P,Bergmeier L,Lee SF,Progulske-Fox A,Harris AC,Aitken A,Bleiweis AS,Lehner T

    更新日期：1989-11-20 00:00:00

  • Movement of the 3'-end of 16 S RNA towards S21 during activation of 30 S ribosomal subunits.

    abstract：:Fluorescence techniques were used to study conformational changes that occur in inactive E. coli 30 S ribosomal subunits during activation by heating in 12 mM Mg2+. Activation is associated with movement of a fluorophore on the 3'-end of 16 S RNA into a less polar environment and towards a probe on the cysteine thiol ...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(84)81037-6

    authors： Odom OW,Stöffler G,Hardesty B

    更新日期：1984-07-23 00:00:00

  • Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells.

    abstract：:The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but M...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(89)80586-1

    authors： Okada Y,Konomi H,Yada T,Kimata K,Nagase H

    更新日期：1989-02-27 00:00:00

  • Feedback regulation of Ras2 guanine nucleotide exchange factor (Ras2-GEF) activity of Cdc25p by Cdc25p phosphorylation in the yeast Saccharomyces cerevisiae.

    abstract：:Ras-GEF Cdc25p has been found to be hyperphosphorylated upon glucose addition. This work provides evidence indicating that PKA activity positively regulates the degree of Cdc25p phosphorylation, and that the intracellular association of Cdc25p and Ras2p is independent of PKA activity. In vitro experiments revealed tha...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/j.febslet.2010.11.006

    authors： Jian D,Aili Z,Xiaojia B,Huansheng Z,Yun H

    更新日期：2010-12-01 00:00:00

  • Characterization of yeast fructose-2,6-bisphosphate 6-phosphatase.

    abstract：:To obtain information on the biological significance of yeast fructose-2,6-bisphosphate 6-phosphatase, kinetic data of the purified enzyme [(1987) Eur. J. Biochem. 164, 27-30] have been measured. Maximal activity was found between pH 6 and 7, the apparent Michaelis constant with fructose 2,6-bisphosphate was 7.2 micro...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(88)80547-7

    authors： Plankert U,Purwin C,Holzer H

    更新日期：1988-10-24 00:00:00

  • Peroxiredoxin-I is an autoimmunogenic tumor antigen in non-small cell lung cancer.

    abstract：:In eukaryotic cells, peroxiredoxins are both antioxidants and regulators of H(2)O(2)-mediated signaling. We previously found that peroxiredoxin-I (Prx-I) was overexpressed in non-small cell lung cancer (NSCLC) tissue. Since overexpressed protein can induce a humoral immune response, we examined whether serum from NSCL...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/j.febslet.2005.04.028

    authors： Chang JW,Lee SH,Jeong JY,Chae HZ,Kim YC,Park ZY,Yoo YJ

    更新日期：2005-05-23 00:00:00

  • The role of apoE in inhibitory effects of apoE-rich HDL on platelet function.

    abstract：:Apolipoprotein E- (ApoE-) rich high-density lipoprotein (HDL), which was prepared from the bound fraction of normolipemic volunteers on heparin-Sepharose and from a hyperalphalipoproteinemic patient, potently inhibited aggregation of human platelets in a dose-dependent fashion. Dimyristoyl phosphatidylcholine liposome...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(91)80449-d

    authors： Higashihara M,Kinoshita M,Teramoto T,Kume S,Kurokawa K

    更新日期：1991-04-22 00:00:00

  • p21ras contributes to HIV-1 activation in T-cells.

    abstract：:Activation of T-cells infected by HIV-1 results in activation of long terminal repeat (LTR)-dependent viral transcription and ultimately the production of infectious virus. Although full T-cell activation requires a complex series of intracellular signals, including protein kinase C activation, calcium mobilisation, a...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(92)80633-r

    authors： Baldari CT,Macchia G,Massone A,Telford JL

    更新日期：1992-06-15 00:00:00

  • In vitro synthesis, tetramerization and single channel characterization of virus-encoded potassium channel Kcv.

    abstract：:Chlorella virus-encoded membrane protein Kcv represents a new class of potassium channel. This 94-amino acids miniature K(+) channel consists of two trans-membrane alpha-helix domains intermediated by a pore domain that contains a highly conserved K(+) selectivity filter. Therefore, as an archetypal K(+) channel, the ...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/j.febslet.2007.02.005

    authors： Shim JW,Yang M,Gu LQ

    更新日期：2007-03-06 00:00:00

  • The low energy emitting states of the Lhca4 subunit of higher plant photosystem I.

    abstract：:The selectively red excited emission spectrum, at room temperature, of the in vitro reconstituted Lhca4, has a pronounced non-equilibrium distribution, leading to enhanced emission from the directly excited low-energy pigments. Two different emitting forms (or states), with maximal emission at 713 and 735nm (F713 and ...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/j.febslet.2005.02.057

    authors： Zucchelli G,Morosinotto T,Garlaschi FM,Bassi R,Jennings RC

    更新日期：2005-04-11 00:00:00

  • Theoretical study on binding of Hoechst 33258 with oligonucleotides.

    abstract：:Computer modelling with an energy minimization procedure is used here to obtain stereochemical and energetic details for complexes of the dye Hoechst 33258 with different oligonucleotide sequences. An optimised model of the dye with d(A)5 X d(T)5 is in conformity with previous proposed models. It has bifurcated hydrog...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(87)80120-5

    authors： Gopalakrishna K,Kalia A,Royyuru AK,Mrigank,Atreyi M,Rao MV,Kothekar V

    更新日期：1987-05-04 00:00:00

  • EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368.

    abstract：:Gap junctions (GJs) traverse apposing membranes of neighboring cells to mediate intercellular communication by passive diffusion of signaling molecules. We have shown previously that cells endocytose GJs utilizing the clathrin machinery. Endocytosis generates cytoplasmic double-membrane vesicles termed annular gap jun...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/j.febslet.2014.01.048

    authors： Fong JT,Nimlamool W,Falk MM

    更新日期：2014-03-03 00:00:00

  • Mutations at residues Tyr771 and Tyr783 of phospholipase C-gamma1 have different effects on cell actin-cytoskeleton organization and cell proliferation in CCL-39 cells.

    abstract：:Currently a central question that remains unresolved is the potential importance of phospholipase C (PLC)-gamma1 in cell mitogenesis. In this study, we introduced wild-type PLC-gamma1 plasmid and mutants Y771F and Y783F into CCL-39 fibroblasts and investigated their effect on host cell functions. To our surprise, Y771...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/s0014-5793(98)00063-5

    authors： Pei ZD,Williamson JR

    更新日期：1998-02-13 00:00:00

  • Na(+)-dependent high affinity uptake of L-glutamate in primary cultures of human fibroblasts isolated from three different types of tissue.

    abstract：:Cultured human fibroblasts isolated from embryonic muscle, skin and peripheral nerve tissues were found to accumulate [3H]L-glutamate by a Na(+)-dependent uptake process strongly inhibited by several glutamate/aspartate analogues including D- and L-aspartate, D- and L-threo-3-hydroxyaspartate and L-trans-pyrrolidine-2...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(94)80382-x

    authors： Balcar VJ,Shen J,Bao S,King NJ

    更新日期：1994-02-14 00:00:00

  • New polypeptide components purified from mamba venom.

    abstract：:New polypeptide components have been isolated from Dendroaspis angusticeps venom using chromatography. Two polypeptides containing 59 and 57 amino acids, called 'DaE1' and 'DaE2' respectively, have been purified to homogeneity and fully sequenced. Spectrometric analysis yielded masses of 6631.5 and 6389.0 Da, respecti...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/s0014-5793(01)02201-3

    authors： Tytgat J,Vandenberghe I,Ulens C,Van Beeumen J

    更新日期：2001-03-02 00:00:00

  • Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle.

    abstract：:Pin2/TRF1 was independently identified as a telomeric DNA-binding protein (TRF1) that regulates telomere length, and as a protein (Pin2) that can bind the mitotic kinase NIMA and suppress its lethal phenotype. We have previously demonstrated that Pin2/TRF1 levels are cell cycle-regulated and its overexpression induces...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/s0014-5793(02)02363-3

    authors： Nakamura M,Zhou XZ,Kishi S,Lu KP

    更新日期：2002-03-13 00:00:00

  • Triphenyltin chloride inhibits superoxide production by human neutrophils stimulated with a surface active agent.

    abstract：:Treatment of human neutrophils with triphenyltin chloride (TPTCl)-inhibited superoxide (O-2) production stimulated with phorbol myristate acetate (PMA). TPTCl was more potent as inhibitor of O-2 production than other phenyltin compounds. The O-2 production by the xanthine oxidase-acetaldehyde system was not inhibited ...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/0014-5793(83)80296-8

    authors： Matsui H,Wada O,Ushijima Y,Akuzawa T

    更新日期：1983-12-12 00:00:00

  • Genomic structure and promoter analysis of the rat kir7.1 potassium channel gene (Kcnj13).

    abstract：:In the brain inwardly rectifying potassium channel Kir7.1 subunits are predominantly expressed in the choroid plexus and meninges. To investigate this tissue-specific expression pattern, we characterized the genomic organization and the 5' proximal promoter of the rat Kir7.1 gene (Kcnj13). Starting from the major tran...

    journal_title：FEBS letters

    pub_type： 杂志文章

    doi：10.1016/s0014-5793(00)02092-5

    authors： Döring F,Karschin A

    更新日期：2000-10-20 00:00:00