Abstract:
:The initial processes of platelet activation by platelet-activating factor (PAF) were observed by stopped-flow light scattering and fluorometry. The binding of PAF to rabbit platelets did not change the membrane fluidity, though it caused the removal of calcium from internal stores and induced concomitantly platelet shape changes. These results were quite in contrast to those by thrombin and ADP activation, where the membrane fluidity increased before the calcium release from the internal stores. The increased membrane fluidity in the latter system seemed to be used to transmit an external signal to a GTP-binding protein.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ohga Y,Nakanishi Mdoi
10.1016/0014-5793(86)80034-5subject
Has Abstractpub_date
1986-10-20 00:00:00pages
173-6issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(86)80034-5journal_volume
207pub_type
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