Abstract:
:Phosphorylcholine (PC) is a classical ligand of C-reactive protein (CRP), a clinically important acute phase protein. In search of new ligands, CRPs were affinity-purified from several pathological samples, which exhibited distinct molecular variants induced in different diseases. Both glycosylated and non-glycosylated CRPs showed calcium-independent differential-binding to Staphylococcus aureus cell-surface Protein A. CRP possesses separate binding sites for Protein A and PC with different binding constants. We have demonstrated that Protein A is another ligand in addition to PC establishing an extended definition of CRP. Protein A binding may impart immunomodulatory roles of CRP in combating microorganisms or other foreign materials.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Das T,Mandal C,Mandal Cdoi
10.1016/j.febslet.2004.08.072keywords:
subject
Has Abstractpub_date
2004-10-08 00:00:00pages
107-13issue
1-2eissn
0014-5793issn
1873-3468pii
S0014579304010920journal_volume
576pub_type
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