Abstract:
:Mona is an SH3 and SH2 domain-containing adapter molecule that is induced during monocytic differentiation. Here we have first shown that M-CSFR is the major Mona partner in M-CSF signaling, the interaction being mediated through tyrosine 697 of the receptor. Next we asked whether Mona expression would alter the Ras/MAP kinase pathway since Mona is a likely competitor of Grb2 for binding to M-CSFR. We found that M-CSF induced late and massive phosphorylation of ERK molecules in Mona-expressing myeloid cells compared to non-expressing cells. These results suggest that Mona expression might modify M-CSF signaling during monocytic differentiation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bourgin C,Bourette R,Mouchiroud G,Arnaud Sdoi
10.1016/s0014-5793(00)01906-2keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
113-7issue
2-3eissn
0014-5793issn
1873-3468pii
S0014-5793(00)01906-2journal_volume
480pub_type
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