Abstract:
:Myocyte stress 1 (MS1) is a recently described striated muscle actin-binding protein that is up-regulated in the early stages of pressure overload left ventricular hypertrophy. The aim of this study was to determine whether MS1 induces cellular hypertrophy and protects against apoptosis. Over-expressed MS1 co-localized with actin in H9c2 cells and altered expression of genes of the myocardin-related transcription factor (MRTF)/serum response factor (SRF) transcriptional pathways and in addition the apoptosis repressor with caspase recruitment domain (Nol3) gene. The size of cells over-expressing MS1 was significantly increased by 55% and over-expression of MS1 dramatically inhibited staurosporine-induced apoptosis by 89%. These findings suggest the involvement of MS1 in cellular hypertrophy and protection against apoptosis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Koekemoer AL,Chong NW,Goodall AH,Samani NJdoi
10.1016/j.febslet.2009.08.011subject
Has Abstractpub_date
2009-09-03 00:00:00pages
2964-7issue
17eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00628-0journal_volume
583pub_type
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