The farnesoid X receptor induces very low density lipoprotein receptor gene expression.

abstract：:The C-Jun N-terminal Kinase (JNK) inhibitor SP600125 is widely used to inhibit the JNK-mediated Bax activation and cell apoptosis. However, this report demonstrates that SP600125 synergistically enhances the dihydroartemisinin (DHA)-induced human lung adenocarcinoma cell apoptosis by accelerating Bax translocation and...

journal_title：FEBS letters

authors： Lu YY,Chen TS,Wang XP,Qu JL,Chen M

更新日期：2010-09-24 00:00:00

abstract：:A wide variety of phospholipase A2 inhibitors blocks intra-Golgi protein transport reconstituted in a cell-free system. Phospholipase A2 activity detectable under the protein transport assay conditions is actually inhibited by the inhibitors. There is a good correlation between the inhibition of protein transport and ...

journal_title：FEBS letters

authors： Tagaya M,Henomatsu N,Yoshimori T,Yamamoto A,Tashiro Y,Fukui T

更新日期：1993-06-14 00:00:00

abstract：:Locus control regions (LCRs) are cis-acting elements that confer position-independent and copy-number-dependent expression upon associated genes in transgenic mice. Here we show the second example of the use of an LCR (the rat LAP LCR) in a stable expression vector system, used here in conjunction with the rat liver (...

journal_title：FEBS letters

authors： Shelton PA,Dart C

更新日期：1996-08-12 00:00:00

abstract：:Amylin, a 37 amino acid product of pancreatic beta-cells, inhibits insulin-stimulated radioglucose incorporation into muscle glycogen. In the current study, we exercised rats and then prelabelled the glycogen pool by infusing [3-3H]glucose along with glucose and insulin. Subsequent amylin administration increased the ...

journal_title：FEBS letters

authors： Young AA,Carlo P,Smith P,Wolfe-Lopez D,Pittner R,Wang MW,Rink T

更新日期：1993-11-22 00:00:00

abstract：:SecM in Escherichia coli has two functionally crucial regions. The arrest motif near the C-terminus interacts with the ribosomal exit tunnel to arrest its own translational elongation. The signal sequence at the N-terminus directs the SecM nascent polypeptide to the Sec-mediated export pathway to release the arrested ...

journal_title：FEBS letters

authors： Nakamori K,Chiba S,Ito K

更新日期：2014-08-25 00:00:00

abstract：:The triplex structure in vitro is well established; however, no direct evidence has been available concerning its existence in the cell. Using the direct chemical probing here we show that the triplex H structure can exist in E. coli cells at acidic intracellular pH values; this structure differs in some details from ...

journal_title：FEBS letters

authors： Karlovsky P,Pecinka P,Vojtiskova M,Makaturova E,Palecek E

更新日期：1990-11-12 00:00:00

abstract：:Mechanisms underlying the association between fibroblastic growth factor 23 (FGF-23) and inflammation are uncertain. We found that FGF-23 was markedly up-regulated in LPS/INF-γ-induced proinflammatory M1 macrophages and Hyp mouse-derived peritoneal macrophages, but not in IL-4-induced M2 anti-inflammatory macrophages....

journal_title：FEBS letters

authors： Han X,Li L,Yang J,King G,Xiao Z,Quarles LD

更新日期：2016-01-01 00:00:00

abstract：:We report here the molecular cloning, nucleotide sequence, and predicted amino acid sequence of an alpha-subunit of the developmentally useful model, Artemia. The amino acid sequence shows divergence from that of mammals, birds, Torpedo, and Drosophila. However, regions in the putative ATP binding and transmembrane do...

journal_title：FEBS letters

authors： Baxter-Lowe LA,Guo JZ,Bergstrom EE,Hokin LE

更新日期：1989-10-23 00:00:00

abstract：:We employed cDNA representational difference analysis to identify new genes that are upregulated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a human hepatoblastoma cell line HepG2. We isolated several TCDD-responsive cDNAs. Sequence analysis revealed that one of them encodes E16/CD98LC/hLAT1, an integral membrane...

journal_title：FEBS letters

authors： Sarkar D,Kambe F,Hirata A,Iseki A,Ohmori S,Seo H

更新日期：1999-12-03 00:00:00

abstract：:Inducible nitric oxide (NO) synthase (iNOS) appears to be a marker of tumor progression in colon carcinogenesis. Here we investigated effects of NO on selected chemokines that differentially regulate angiogenesis, namely pro-angiogenic interleukin (IL)-8 as well as tumor-suppressive interferon-inducible protein-10 (IP...

journal_title：FEBS letters

authors： Hellmuth M,Paulukat J,Ninic R,Pfeilschifter J,Mühl H

更新日期：2004-04-09 00:00:00

abstract：:In order to elucidate the molecular mechanisms responsible for the specific lipid-protein interactions, we have undertaken structural and idiotypic analyses of a monoclonal antibody, PS4A7, which binds specifically to phosphatidylserine (PS). Here we showed that one of the anti-idiotypic monoclonal antibodies raised a...

journal_title：FEBS letters

authors： Reza F,Igarashi K,Tokita S,Asai K,Aoki J,Asaoka Y,Umeda M,Inoue K

更新日期：1994-02-21 00:00:00

abstract：:Neopterin is synthesized by human monocyte-derived macrophages primarily upon stimulation with the cytokine interferon-gamma. We studied the influence of neopterin on the generation of reactive oxygen species (ROS) in human peripheral blood neutrophils. Radical formation was measured using a biochemiluminometer. Neutr...

journal_title：FEBS letters

authors： Razumovitch JA,Semenkova GN,Fuchs D,Cherenkevich SN

更新日期：2003-08-14 00:00:00

abstract：:Replacements of Asp-295 by Asn (D295N) and Glu (D295E) decreased the catalytic center activity of Leuconostoc mesenteroides sucrose phosphorylase to about 0.01% of the wild-type level (k(cat)=200s(-1)). Glucosylation and deglucosylation steps of D295N were affected uniformly, approximately 10(4.3)-fold, and independen...

journal_title：FEBS letters

authors： Mueller M,Nidetzky B

更新日期：2007-04-03 00:00:00

abstract：:Membrane proteins are usually solubilized in polar solvents by incorporation into micelles. Even for small membrane proteins these mixed micelles have rather large molecular masses, typically beyond 50000 Da. The NMR technique TROSY (transverse relaxation-optimized spectroscopy) has been developed for studies of struc...

journal_title：FEBS letters

authors： Fernández C,Hilty C,Bonjour S,Adeishvili K,Pervushin K,Wüthrich K

更新日期：2001-08-31 00:00:00

abstract：:Several lines of evidence led to the conclusion that mammalian ribosomal protein synthesis is a highly organized biological process in vivo. A wealth of data support the concept according to which tRNA aminoacylation, formation of the ternary complex on EF1A and delivery of aminoacyl-tRNA to the ribosome is a processi...

journal_title：FEBS letters

authors： Mirande M

更新日期：2010-01-21 00:00:00

abstract：:The phylogenetic distribution of divergently related protein families into the three domains of life (archaea, bacteria and eukaryotes) can signify the presence or absence of entire cellular processes in these domains and their ancestors. We can thus study the emergence of the major transitions during cellular evoluti...

journal_title：FEBS letters

authors： Ouzounis C,Kyrpides N

更新日期：1996-07-22 00:00:00

abstract：:The nature of the G-proteins present in the pre- and post-synaptic plasma membranes and in the synaptic vesicles of cholinergic nerve terminals purified from the Torpedo electric organ was investigated. In pre- and post-synaptic plasma membranes, Bordetella pertussis toxin, known to catalyze the ADP-ribosylation of th...

journal_title：FEBS letters

authors： Toutant M,Bockaert J,Homburger V,Rouot B

更新日期：1987-09-28 00:00:00

abstract：:The pl6INK4a tumor suppressor negatively regulates progression through the G1 phase of the mammalian cell cycle. To mimic the downmodulation of p16INK4a commonly seen in cancer, we designed and characterized a hammerhead ribozyme against exon E1alpha of the murine pl6INK4a transcript. Stable expression of the ribozyme...

journal_title：FEBS letters

authors： Nylandsted J,Rohde M,Bartek J,Strauss M

更新日期：1998-09-25 00:00:00

abstract：:The interaction of vinculin with actin filaments was investigated by methods which exclude interference by contaminating proteins which may occur in vinculin preparations. Vinculin which was blotted from SDS-polyacrylamide gels onto nitrocellulose, was stained specifically by fluorescently labeled polymeric actin (100...

journal_title：FEBS letters

authors： Ruhnau K,Wegner A

更新日期：1988-02-08 00:00:00

abstract：:In this study we identify the molecules involved in the MAPK signal transduction pathway (Ras, Raf-1, Mek, Mek-P and MAPK) in highly purified endosomal fractions isolated from rat liver. Biochemical analysis shows that only the early-sorting endocytic compartment contains activated Raf-1 and Mek. Finally, the exogenou...

journal_title：FEBS letters

authors： Pol A,Calvo M,Enrich C

更新日期：1998-12-11 00:00:00

abstract：:Single channel recording techniques have been applied to neurons cultured from the hippocampus and the respiratory area of the brain stem of fetal rats in order to search for nicotinic acetylcholine receptors (nAChR) in the central nervous system. In addition to acetylcholine (ACh), the potent and specific agonist (+)...

journal_title：FEBS letters

authors： Aracava Y,Deshpande SS,Swanson KL,Rapoport H,Wonnacott S,Lunt G,Albuquerque EX

更新日期：1987-09-28 00:00:00

abstract：:A mouse cDNA encoding for matrilin-3, the third member of the novel matrilin family of extracellular matrix proteins, was cloned. The protein precursor of 481 amino acids consists of a putative signal peptide, a short positively charged sequence, a single vWFA-like domain followed by four epidermal growth factor-like ...

journal_title：FEBS letters

authors： Wagener R,Kobbe B,Paulsson M

更新日期：1997-08-11 00:00:00

abstract：:Epidermal growth factor (EGF) dose-dependently enhanced the induction of tyrosine aminotransferase and tryptophan oxygenase by glucocorticoids in primary cultures of adult rat hepatocytes without itself having any effect on these enzymes in the absence of glucocorticoids. The amplifications were observed even with dex...

journal_title：FEBS letters

authors： Kido H,Fukusen N,Katunuma N

更新日期：1987-11-02 00:00:00

abstract：:The regulation by insulin and carbohydrates of the gene expression of three key enzymes involved in glucose metabolism was studied in the liver of the Wistar fatty rat, a model of obese non-insulin-dependent diabetes mellitus. A high glucose or fructose diet, or insulin administration caused a similar magnitude of inc...

journal_title：FEBS letters

authors： Noguchi T,Matsuda T,Tomari Y,Yamada K,Imai E,Wang Z,Ikeda H,Tanaka T

更新日期：1993-08-09 00:00:00

abstract：:Tyrosine O-sulfation is one of the post-translational modification processes that occur to membrane proteins and secreted proteins in eukaryotes. Tyrosylprotein sulfotransferase (TPST) is responsible for this modification, and in this report, we describe the expression pattern and the biological role of TPST-A in the ...

journal_title：FEBS letters

authors： Kim TH,Hwang SB,Jeong PY,Lee J,Cho JW

更新日期：2005-01-03 00:00:00

abstract：:Oxysterols result from cholesterol by enzymatic or oxidative processes. Some exert cytotoxic effects leading to necrosis or apoptosis. Detoxification of these compounds mainly occurs in the liver and requires transport from peripheral tissues towards it. Some ATP-binding cassette transporters are involved in export of...

journal_title：FEBS letters

authors： Engel T,Kannenberg F,Fobker M,Nofer JR,Bode G,Lueken A,Assmann G,Seedorf U

更新日期：2007-04-17 00:00:00

abstract：:Photoaffinity crosslinking has been utilized to probe the nature of the ligand-receptor interface for a number of G protein-coupled receptor systems. Often the photoreactive benzophenone moiety incorporated in the ligand is found to react with a methionine in the receptor. We introduced methionines one-at-a-time into ...

journal_title：FEBS letters

authors： Wittelsberger A,Thomas BE,Mierke DF,Rosenblatt M

更新日期：2006-03-20 00:00:00

abstract：:The photocycle of the light-adapted purple membrane was studied with a time-resolved fluorometry apparatus: fluorescence of the sample suspension (greater than 660 nm) was pumped with a 633-nm cw laser and the temporal change induced by a 532-nm pulsed laser was measured with a photon-counting-type transient recorder....

journal_title：FEBS letters

authors： Ohtani H,Itoh H,Shinmura T

更新日期：1992-06-22 00:00:00

abstract：:Non-alcoholic fatty liver disease is tightly associated with insulin resistance, type 2 diabetes and obesity, but the molecular links between hepatic fat accumulation and insulin resistance are not fully identified. Excessive accumulation of triglycerides (TG) is one the main characteristics of non-alcoholic fatty liv...

journal_title：FEBS letters

authors： Denechaud PD,Dentin R,Girard J,Postic C

更新日期：2008-01-09 00:00:00

abstract：:A number of human diseases can be linked to aberrations in protein folding which cause an imbalance in protein homeostasis. Molecular chaperones, including heat shock proteins, act to assist protein folding, stability and activity in the cell. Attention has begun to focus on modulating the expression and/or activity o...

journal_title：FEBS letters

authors： Powers MV,Workman P

更新日期：2007-07-31 00:00:00