Abstract:
:Exposure of a human lung epithelial cancer cell-line to hypo-osmotic media led to a marked increase in the rate of efflux from the cells of taurine, a non-essential sulfonic amino acid. The osmotically-activated taurine efflux was inhibited by a range of known Cl- channel blockers, the most potent of which were NPPB and 1,9-dideoxyforskolin. These reagents were similarly effective at inhibiting the osmotically-activated efflux of I-, a known substrate of volume-activated Cl- channels. The results are consistent with the hypothesis that volume-regulatory taurine release from these cells is mediated by a volume-activated Cl- channel.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kirk K,Kirk Jdoi
10.1016/0014-5793(93)81630-isubject
Has Abstractpub_date
1993-12-20 00:00:00pages
153-8issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(93)81630-Ijournal_volume
336pub_type
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