Abstract:
:A link between alterations in cholesterol homeostasis and Alzheimer's disease (AD) is nowadays widely accepted. However, the molecular mechanism/s underlying such link remain unclear. Numerous experimental evidences support the view that changes in neuronal membrane cholesterol levels and/or subcellular distribution determine the aberrant accumulation of the amyloid peptide in the disease. Still, this view comes from rather contradictory data supporting the existence of either high or low brain cholesterol content. This is of particular concern considering that therapeutical strategies aimed to reduce cholesterol levels are already being tested in humans. Here, we review the molecular mechanisms proposed and discuss the perspectives they open.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ledesma MD,Dotti CGdoi
10.1016/j.febslet.2006.06.038subject
Has Abstractpub_date
2006-10-09 00:00:00pages
5525-32issue
23eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00745-9journal_volume
580pub_type
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