Abstract:
:Curcumin, the yellow pigment from Curcuma longa, has been shown to possess tumoricidal activity. We have earlier reported the induction of apoptosis in AK-5, rat histiocytic cells by curcumin leading to the inhibition of tumor growth in vivo. In this study we have observed differential activation status in host macrophages and NK cells induced by curcumin during the spontaneous regression of subcutaneously transplanted AK-5 tumors. Closer scrutiny of the cytokine profile and nitric oxide (NO) production by immune cells showed an initial downregulation of Th1 cytokine response and NO production by macrophages, and their upregulation in NK cells, which picked-up upon prolonged treatment with curcumin, culminating in a stronger tumoricidal effect. These studies suggest that the host macrophages and NK cells play an important modulatory role in the remission of AK-5 tumor.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bhaumik S,Jyothi MD,Khar Adoi
10.1016/s0014-5793(00)02089-5keywords:
subject
Has Abstractpub_date
2000-10-13 00:00:00pages
78-82issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(00)02089-5journal_volume
483pub_type
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