Abstract:
:Expression of androgen receptor (AR) in prostate epithelial cells is thought to regulate cell proliferation, differentiation, and survival. However, the molecular mechanisms remain unclear. We report that re-expression of AR in PC-3 human prostate cancer cell line resulted in upregulation of IFI16 protein, a negative regulator of cell growth. We found that the IFI16 protein bound to AR in a ligand-dependent manner and the DNA-binding domain (DBD) of the AR was sufficient to bind IFI16. Furthermore, re-expression of IFI16 protein in LNCaP prostate cancer cells, which do not express IFI16 protein, resulted in downregulation of AR expression and an inhibition of the expression of AR target genes. Our observations identify a role for IFI16 protein in AR-mediated functions.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Alimirah F,Chen J,Xin H,Choubey Ddoi
10.1016/j.febslet.2006.02.015keywords:
subject
Has Abstractpub_date
2006-03-06 00:00:00pages
1659-64issue
6eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00197-9journal_volume
580pub_type
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