Molecular mechanism of molt-inhibiting hormone (MIH) induced suppression of ecdysteroidogenesis in the Y-organ of mud crab: Scylla serrata.

Abstract:

:The present study was focused on the regulation of ecdysteroidogenesis in the Y-organ of Scylla serrata during molting cycle. A strong expression of molt-inhibiting hormone (MIH) and phosphorylation of ERK was predominantly observed in the postmolt and intermolt stages of Y-organs, whereas protein kinase C, steroidogenic acute regulatory protein (StAR) and cytochrome P450(scc) activity were exclusively seen in the premolt stages. Interestingly, inhibition of ERK phosphorylation by PD98059 in the early postmolt (A), middle postmolt (B) and intermolt (C) stages resulted in the prominent expression of PKC and StAR in the postmolt stages. This result indicates that phosphorylation of ERK is required for suppression of ecdysteroid biosynthesis with the involvement of protein kinase C, and StAR protein.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Imayavaramban L,Dhayaparan D,Devaraj H

doi

10.1016/j.febslet.2007.09.029

subject

Has Abstract

pub_date

2007-11-13 00:00:00

pages

5167-72

issue

27

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(07)01011-3

journal_volume

581

pub_type

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