Balancing presynaptic release and endocytic membrane retrieval at hair cell ribbon synapses.

Abstract:

:The timely and reliable processing of auditory and vestibular information within the inner ear requires highly sophisticated sensory transduction pathways. On a cellular level, these demands are met by hair cells, which respond to sound waves - or alterations in body positioning - by releasing glutamate-filled synaptic vesicles (SVs) from their presynaptic active zones with unprecedented speed and exquisite temporal fidelity, thereby initiating the auditory and vestibular pathways. In order to achieve this, hair cells have developed anatomical and molecular specializations, such as the characteristic and name-giving 'synaptic ribbons' - presynaptically anchored dense bodies that tether SVs prior to release - as well as other unique or unconventional synaptic proteins. The tightly orchestrated interplay between these molecular components enables not only ultrafast exocytosis, but similarly rapid and efficient compensatory endocytosis. So far, the knowledge of how endocytosis operates at hair cell ribbon synapses is limited. In this Review, we summarize recent advances in our understanding of the SV cycle and molecular anatomy of hair cell ribbon synapses, with a focus on cochlear inner hair cells.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Pangrsic T,Vogl C

doi

10.1002/1873-3468.13258

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

3633-3650

issue

21

eissn

0014-5793

issn

1873-3468

journal_volume

592

pub_type

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