Abstract:
:The timely and reliable processing of auditory and vestibular information within the inner ear requires highly sophisticated sensory transduction pathways. On a cellular level, these demands are met by hair cells, which respond to sound waves - or alterations in body positioning - by releasing glutamate-filled synaptic vesicles (SVs) from their presynaptic active zones with unprecedented speed and exquisite temporal fidelity, thereby initiating the auditory and vestibular pathways. In order to achieve this, hair cells have developed anatomical and molecular specializations, such as the characteristic and name-giving 'synaptic ribbons' - presynaptically anchored dense bodies that tether SVs prior to release - as well as other unique or unconventional synaptic proteins. The tightly orchestrated interplay between these molecular components enables not only ultrafast exocytosis, but similarly rapid and efficient compensatory endocytosis. So far, the knowledge of how endocytosis operates at hair cell ribbon synapses is limited. In this Review, we summarize recent advances in our understanding of the SV cycle and molecular anatomy of hair cell ribbon synapses, with a focus on cochlear inner hair cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Pangrsic T,Vogl Cdoi
10.1002/1873-3468.13258subject
Has Abstractpub_date
2018-11-01 00:00:00pages
3633-3650issue
21eissn
0014-5793issn
1873-3468journal_volume
592pub_type
杂志文章,评审相关文献
FEBS LETTERS文献大全abstract::The addition of hepatocyte growth factor (HGF) to rat hepatocytes in primary culture resulted in the formation of inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and 1,2-diacylglycerol (DG) by a phosphoinositide-specific phospholipase C (PI-PLC). DG showed a biphasic increase; the first phase, corresponding with the peak ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(92)80554-t
更新日期:1992-02-10 00:00:00
abstract::Catenins are peripheral cytoplasmic proteins originally identified in association with the mouse epithelial cell adhesion molecule E-cadherin. Molecular cloning and primary structure analysis demonstrated that alpha-catenin is homologous to vinculin and the beta-catenin is homologous to human plakoglobin and the Droso...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(94)01205-9
更新日期:1994-11-28 00:00:00
abstract::Ca(2+) entering cells through store-operated channels (SOCs) affects most cell functions, and excess SOC is associated with pathologies. The molecular makeup of SOCs and their mechanisms of gating were clarified with the discovery of the Orais and STIM1. Another form of SOCs are the TRPCs. STIM1 gates both Orai and TR...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/j.febslet.2009.11.078
更新日期:2010-05-17 00:00:00
abstract::The effect of the uremic solute indoxyl sulfate (IS) on scavenging superoxide anion radicals (O(2)(*-)) generated from both the xanthine/xanthine oxidase (X/XO) system and activated neutrophils was investigated by electron paramagnetic resonance spectroscopy, combined with 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrr...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2010.04.046
更新日期:2010-07-02 00:00:00
abstract::Transient receptor potential (TRP) proteins are sensory-related cation channels. TRPV subfamily responds to vanilloids, generating a Ca(2+) current. TRPV1, a thermal-sensitive non-selective ion channel, possesses six transmembrane helices and the intracellular N- and C-terminal domains. The latter contains the PIP(2) ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2012.03.030
更新日期:2012-04-24 00:00:00
abstract::1H NMR spectra of skinned rabbit muscle fibers show a group of relatively sharp resonance lines which presumably originate from highly mobile protein domains. Comparison with the spectrum of myosin subfragment 1 suggests that these signals may come at least partly from mobile regions of the myosin head. NMR could poss...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(92)80063-m
更新日期:1992-02-24 00:00:00
abstract::NDRG1 is phosphorylated by SGK1 (but not PKB) in vivo at three residues each contained within three nonapeptide repeats. Here, we demonstrate that this nonapeptide, like the NDRG1 protein, is phosphorylated by SGK1, but not by PKBalpha or RSK1 in vitro. The inability of PKBalpha and RSK1 to phosphorylate the nonapepti...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2004.12.069
更新日期:2005-02-14 00:00:00
abstract::Mutations in retinol dehydrogenase 12 (RDH12) cause severe retinal degeneration. However, some of the disease-associated RDH12 mutants retain significant catalytic activity, indicating the existence of additional pathophysiological mechanisms. This study demonstrates that the catalytically active T49M and I51N mutants...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2009.12.009
更新日期:2010-02-05 00:00:00
abstract::Treatment of human lymphoblastoid (Daudi) cells with interferons inhibits cell proliferation in culture within 24 h. The failure of cell growth has been shown to be associated with impaired processing and decreased stability of newly replicated DNA. Because there is a close relationship between DNA replication and pro...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(84)80469-x
更新日期:1984-06-04 00:00:00
abstract::Purified barley leaf ADP-glucose pyrophosphorylase, a key enzyme of the starch synthesis in the chloroplast stroma, was analysed with respect to its possible regulation by factors defining the metabolic/effector status of the chloroplast during light and dark conditions. The enzyme required 3-phosphoglyceric acid for ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)00346-4
更新日期:1999-04-01 00:00:00
abstract::Two-dimensional hydrophobic clusters analysis (HCA) was used to compare the distribution of hydrophobic clusters along various actin sequence. HCA-deduced patterns were not altered by amino-acid variations throughout the evolution of actin and we observed similar hydrophobic motifs comprising myosin subfragment-1 ATP-...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(95)01044-f
更新日期:1995-10-16 00:00:00
abstract::Helical filaments of bacterial flagella are built up by a self-assembly process from thousands of flagellin subunits. To clarify how the disordered terminal regions of flagellin interact upon filament formation, polymerization ability of various terminally truncated fragments was investigated. Fragments deprived of 19...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(02)03859-0
更新日期:2003-01-30 00:00:00
abstract::Cloned mouse delta-subtype opioid receptor (DOR1) was expressed in Xenopus oocytes to study the signal transduction. Opioid delta-agonists evoked a calcium-dependent chloride current in oocytes injected with mRNA derived from DOR1, together with that from the alpha subunit of Gi1. The delta-agonist-induced current was...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(93)80677-m
更新日期:1993-11-01 00:00:00
abstract::We studied the effect of point mutation within the putative 11th transmembrane domain (TM11) of the Na(+)/H(+) exchanger NHE1 on the plasma membrane expression. Of the 19 mutants tested, two mutants (Tyr454 or Arg458 replaced by Cys) were retained in the endoplasmic reticulum. Interestingly, Y454C was expressed on the...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(00)02348-6
更新日期:2000-12-29 00:00:00
abstract::The amino acid sequence of EcoRV DNA methyltransferase which methylates the amino group of the 5'-adenine residue of the target sequence GATATC has been found to be closely related to that of three other adenine methyltransferases, DpnII, dam and damT4, the target sequence of which is GATC. Despite large differences o...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(87)80897-9
更新日期:1987-08-10 00:00:00
abstract::Gastrin (G17) and N-carboxymethylgastrin (G17-Gly) have been shown to stimulate the growth of colon cancer cells both in vivo and in vitro. The identity of the receptor mediating these effects is controversial. A recent study demonstrated the presence of a low affinity binding site for G17 and G17-Gly on the DLD-1 hum...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(03)01408-x
更新日期:2004-01-02 00:00:00
abstract::The morula and the mesenchyme blastula nuclei contained approx. 30 nuclear proteins which were preferentially released by limited digestion with DNase I, but no proteins were released from sperm nuclei. While most of the proteins released by DNase I digestion were common to the two embryonic stages, 2 and 6 proteins w...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(84)80311-7
更新日期:1984-04-24 00:00:00
abstract::A novel peptidyl-prolyl cis/trans isomerase was isolated from Escherichia coli cell extract and characterized partially. Determination of the molecular mass by electrospray mass spectrometry indicated a protein of 10102 +/- 2 Da, smaller than cyclophilins or FK 506 binding proteins currently known. The specificity con...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(94)80608-x
更新日期:1994-04-18 00:00:00
abstract::The effective synthesis of the envelope antigen F1 of Y. pestis in E. coli HB101 is mediated by the expression of the caf1M gene. This gene was sequenced, and the protein encoded was found to have a significant homology with the chaperone protein PapD of uropathogenic E. coli. The data presented allow one to suppose C...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(91)80945-y
更新日期:1991-07-29 00:00:00
abstract::Gangliosides and neutral glycolipids of muscles from normal and dystrophic chickens were studied. Total glycolipid content of the degenerating muscles was higher than the normal muscles. In addition, the myopathic muscles contained a ganglioside which was absent in the unaffected muscles from normal and dystrophic chi...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(82)80768-0
更新日期:1982-12-27 00:00:00
abstract::γ-Glutamyl kinase (GK; the PRO1 gene product) is a key enzyme in the Saccharomyces cerevisiae proline biosynthesis pathway. Δpro1 cells are more sensitive to various stresses than wild-type cells, suggesting that GK has an alternative function independent of proline biosynthesis. We show that PRO1 genetically interact...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12318
更新日期:2016-09-01 00:00:00
abstract::Human hepatocellular carcinoma cells (Hep G2) were shown to secrete apo A-I as a proprotein . No apo A-I synthesis could be detected with endothelial cells from human umbilical cord veins. Conversion of proapo A-I into apo A-I is a slow (of the order of hours) process, mediated by a Ca2+/Mg2+-dependent enzyme which is...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(84)81379-4
更新日期:1984-05-07 00:00:00
abstract::In the mouse macrophage-like cell line RAW 264, vacuolar-type (H(+))-ATPase (V-ATPase) inhibitors, bafilomycin A(1) and concanamycin A, increased the level of cyclooxygenase (COX)-2 protein and its mRNA. The V-ATPase inhibitor-induced expression of COX-2 was suppressed by inhibitors of c-jun N-terminal kinase (JNK) an...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2007.08.055
更新日期:2007-10-02 00:00:00
abstract::Small RNAs are non-coding regulatory RNA molecules that control gene expression by mediating mRNA degradation, translational inhibition, or chromatin modification. Virus-derived small RNAs induce silencing of viral RNAs and are essential for antiviral defense in both animal and plant systems. The role of host endogeno...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/j.febslet.2008.06.053
更新日期:2008-08-06 00:00:00
abstract::The effects of protein disulfide isomerase (PDI) on the four structured des species that accumulate in the rate-determining steps of ribonuclease A folding were investigated at pH 8.0 and 15 degrees C. The results indicate that PDI catalyzes the conversion of the kinetically trapped intermediates, des-[26-84] and des-...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(02)02825-9
更新日期:2002-06-19 00:00:00
abstract::We report here the apoptosis of mouse liver nuclei induced in the cytosol of carrot cells by cytochrome c. Several typical characteristics of apoptosis, such as chromatin condensation, margination and apoptotic bodies, were detected. The result of DNA gel electrophoresis showed that DNA was degraded into nucleosomal f...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)00352-x
更新日期:1999-04-01 00:00:00
abstract::The NAD+-requiring enzymes of glycoside hydrolase family 4 (GHF4) contain a region with a conserved Gly-XXX-Gly-Ser (GXGS) motif near their N-termini that is reminiscent of the fingerprint region of the Rossmann fold, a conserved structural motif of classical nicotinamide nucleotide-binding proteins. The function of t...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(02)02641-8
更新日期:2002-04-24 00:00:00
abstract::It has been hypothesized that hyperthermia promotes oxygen-centered free radical formation in cells; however, to date there is no direct evidence of this heat-induced increase in oxygen free radical flux. Using electron paramagnetic resonance (EPR) spin trapping, we sought direct evidence for free radical generation d...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)00779-0
更新日期:1998-07-17 00:00:00
abstract::The trans----cis isomerization of Pro 93 was measured during refolding of bovine ribonuclease A. This isomerization is slow (tau = 500 s) under marginally stable folding conditions of 2.0 M GdmCl, pH 6, at 10 degrees C. However, it is strongly accelerated (tau = 100 s) in samples which, prior to isomerization, had bee...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(86)80408-2
更新日期:1986-03-31 00:00:00
abstract::Herein, we report that dihydrolipoic acid and lipoic acid (LA) plus lipoamide dehydrogenase and NADH denitrosate S-nitrosocaspase 3 (CASP-SNO). In HepG2 cells, S-nitroso-L-cysteine ethyl ester (SNCEE) impeded the activity of caspase 3 (CASP-SH), while a subsequent incubation of the cells in SNCEE-free medium resulted ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2009.10.016
更新日期:2009-11-03 00:00:00