Abstract:
:Recent studies have revealed the presence of an atypical progesterone receptor on the plasma membrane of a relatively small subpopulation of human sperm cells. In this study, we show that the receptor is present in many cells in a latent form and that the receptor function in these cells is switched on asynchronously by increasing intracellular free Ca2+ levels. Under physiological conditions, this process occurs during sperm capacitation, but it can be mimicked by a short sperm exposure to the Ca(2+)-mobilizing agent thapsigargin. These observations suggest a role of Ca2+ as a modulator of nongenomic steroid effects on the cell surface.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mendoza C,Tesarik Jdoi
10.1016/0014-5793(93)80919-lsubject
Has Abstractpub_date
1993-09-06 00:00:00pages
57-60issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(93)80919-Ljournal_volume
330pub_type
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