Abstract:
:The enantiomers of U50,488, ligands highly selective for kappa-opioid receptors, have been prepared by a refined procedure and their optical purity demonstrated. The absolute configuration of (+)-trans-2-pyrrolidinyl-N-methylcyclohexylamine, a chemically versatile intermediate for synthesis of analogs of kappa-opioid receptor ligands with defined chirality, has been determined to be 1S,2S by X-ray crystallographic analysis. This intermediate has been used to synthesize the optically pure U50,488 enantiomers with known absolute configuration.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
DeCosta B,George C,Rothman RB,Jacobson AE,Rice KCdoi
10.1016/0014-5793(87)80315-0subject
Has Abstractpub_date
1987-11-02 00:00:00pages
335-9issue
2eissn
0014-5793issn
1873-3468journal_volume
223pub_type
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