Abstract:
:Transforming growth factors-beta (TGFbeta1, 2 and 3) are secreted in a complex with their propeptides (latency-associated peptide 1 (LAP1), 2 and 3). TGFbeta signaling requires the dissociation of LAP and TGFbeta, a process termed latent TGFbeta activation. This process is a critical but incompletely understood step in the regulation of TGFbeta function. In particular, the extent to which activation mechanisms differ among the three TGFbeta isoforms is relatively unexplored. We show here that alphaVbeta6 binds and activates latent TGFbeta3.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Annes JP,Rifkin DB,Munger JSdoi
10.1016/s0014-5793(01)03280-xkeywords:
subject
Has Abstractpub_date
2002-01-30 00:00:00pages
65-8issue
1-3eissn
0014-5793issn
1873-3468pii
S001457930103280Xjournal_volume
511pub_type
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