Growth factor receptors in helminth parasites: signalling and host-parasite relationships.

Abstract:

:Parasitic helminths remain major pathogens of both humans and animals throughout the world. The success of helminth infections depends on the capacity of the parasite to counteract host immune responses but also to exploit host-derived signal molecules for its development. Recent progress has been made in the characterization of growth factor receptors of various nematode and flatworm parasites with the demonstration that transforming growth factor beta (TGF-beta), epidermal growth factor (EGF) and insulin receptor signalling pathways are conserved in helminth parasites and potentially implicated in the host-parasite molecular dialogue and parasite development.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Dissous C,Khayath N,Vicogne J,Capron M

doi

10.1016/j.febslet.2006.03.046

keywords:

subject

Has Abstract

pub_date

2006-05-22 00:00:00

pages

2968-75

issue

12

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(06)00361-9

journal_volume

580

pub_type

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