Abstract:
:Parasitic helminths remain major pathogens of both humans and animals throughout the world. The success of helminth infections depends on the capacity of the parasite to counteract host immune responses but also to exploit host-derived signal molecules for its development. Recent progress has been made in the characterization of growth factor receptors of various nematode and flatworm parasites with the demonstration that transforming growth factor beta (TGF-beta), epidermal growth factor (EGF) and insulin receptor signalling pathways are conserved in helminth parasites and potentially implicated in the host-parasite molecular dialogue and parasite development.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Dissous C,Khayath N,Vicogne J,Capron Mdoi
10.1016/j.febslet.2006.03.046keywords:
subject
Has Abstractpub_date
2006-05-22 00:00:00pages
2968-75issue
12eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00361-9journal_volume
580pub_type
杂志文章,评审相关文献
FEBS LETTERS文献大全abstract::Using the method of contextual analysis, we have studied the collection of somatic mutations in immunoglobulin genes. It has been found that the emergence of somatic mutations can be based on the reparation of complementarity violations in the heteroduplexes corresponding to complementary palindromes or direct repeats...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(87)80018-2
更新日期:1987-04-06 00:00:00
abstract::Regulatory T-cells (Tregs) are the guardians of peripheral tolerance acting to prevent autoimmune diseases such as systemic lupus erythomatosus (SLE) and rheumatoid arthritis (RA). Defects in Tregs have been reported in these two diseases despite significant differences in their clinical phenotype and pathogenesis. In...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/j.febslet.2011.07.043
更新日期:2011-12-01 00:00:00
abstract::The temperature dependence of the rate constants of the univalent redox steps YzoxSi----YzSi + 1 (i = 0,1,2) and YzoxS3----(YzS4)----YzSo + O2 in the water oxidase was investigated by measuring time resolved absorption changes at 355 nm induced by a laser flash train in dark adapted PS II membrane fragments from spina...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(92)80092-u
更新日期:1992-03-24 00:00:00
abstract::CpG dinucleotides are efficiently methylated in vertebrate genomes except in the CpG islands having a high C+G content. Methylated CpGs are the single most mutated dinucleotide. Sequences surrounding disease causing CpG mutation sites were analyzed from locus-specific mutation databases. Both tetra- and heptanucleotid...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(96)01075-7
更新日期:1996-11-04 00:00:00
abstract::Thioredoxins are a class of small proteins that play a key role in regulating many cellular redox processes. We report here the characterization of the first member of the thioredoxin family in metazoans that is mainly associated with neurons. The Caenorhabditis elegans gene B0228.5 encodes a thioredoxin (TRX-1) that ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2005.12.046
更新日期:2006-01-23 00:00:00
abstract::The effects of cold exposure and T4 administration on fructose 2,6-bisphosphate levels, phosphofructokinase-2 and pyruvate kinase activities were examined in rat brown adipose tissue. Cold adaptation (14 days) gave rise to a 2-fold increase in the amount of fructose 2,6-bisphosphate and phosphofructokinase-2 activity,...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(88)80804-4
更新日期:1988-02-29 00:00:00
abstract::In higher eukaryotes the hypermodified guanine analogue, queuine (7-(5-[(1S,4S,5R)-4,5-dihydroxy-2-cyclopentene-1-yl) amino)-methyl)-7-deazaguanine), occurs free or as modified nucleoside (Q) in the anticodon of specific tRNAs. Fast proliferating tissues and tumors contain considerable amounts of free queuine and Q-de...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(90)80877-l
更新日期:1990-06-04 00:00:00
abstract::The bipartite human interleukin-4 (IL-4) receptor was functionally expressed in murine pro-B cells and activated by human IL-4 to evoke intracellular signaling. Mutual association of signal transducing proteins within the receptor complex was then studied in dependence of ligand stimulation. Besides ligand-induced rec...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)01341-6
更新日期:1998-11-13 00:00:00
abstract::alpha-Crystallin, the major protein of the ocular lens, is known to have extensive similarities to small heat shock proteins and to act as a molecular chaperone. The exposure of hydrophobic surfaces on alpha-crystallin was studied by fluorescence spectroscopy using the hydrophobic probe bis-ANS. Upon heating the prote...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(95)00775-5
更新日期:1995-08-07 00:00:00
abstract::RNA molecules have been found to play important roles in DNA double-strand break (DSB) repair, but the exact underlying mechanism remains unclear. Here, we aimed to clarify the function of RNase L, an important ribonuclease in the immune system of vertebrates, in DSB repair. Knockdown of RNase L reduces cell survival ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13426
更新日期:2019-06-01 00:00:00
abstract::Cytosolic extracts of trout and turkey erythrocytes were tested for their immunoreactivity with polyclonal and monoclonal antibodies to retinal arrestin (S-antigen), a cytosolic protein of photoreceptor cells involved in the desensitization of rhodopsin. After adsorption or immunoaffinity chromatography of the extract...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(89)81663-1
更新日期:1989-12-04 00:00:00
abstract::Here we make a brief survey of the present state of antibiotic research and use. We also describe a novel antibiotic that contains a basic peptide covalently bound to a morpholino oligonucleotide. ...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/j.febslet.2013.10.048
更新日期:2014-01-03 00:00:00
abstract::Raman spectra of active Na+,K+-ATPase from pig kidney and membrane-bound products of its two-stage trypsinolysis, including alpha-subunit hydrophobic regions as well as the intact beta-subunit and hydrophobic regions of alpha- and beta-subunits, were measured to calculate the secondary structure of hydrophilic and hyd...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(88)80905-0
更新日期:1988-01-25 00:00:00
abstract::Little is known about the mechanisms underlying calcium-induced Ca2+ release (CICR) in plants. The slow-activating vacuolar (SV) channel is both permeable to, and activated by Ca2+, and is therefore a prime candidate for a role in CICR. Cytosol-side-out vacuolar membrane vesicles loaded with 45Ca2+ showed voltage- and...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)01109-6
更新日期:1999-09-10 00:00:00
abstract::A novel peptidyl-prolyl cis/trans isomerase was isolated from Escherichia coli cell extract and characterized partially. Determination of the molecular mass by electrospray mass spectrometry indicated a protein of 10102 +/- 2 Da, smaller than cyclophilins or FK 506 binding proteins currently known. The specificity con...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(94)80608-x
更新日期:1994-04-18 00:00:00
abstract::The yeast Saccharomyces cerevisiae contains two acetyl-CoA synthetase genes, ACS1 and ACS2. While ACS1 transcription is glucose repressible, ACS2 shows coregulation with structural genes of fatty acid biosynthesis. The ACS2 upstream region contains an ICRE (inositol/choline-responsive element) as an activating sequenc...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(97)01085-5
更新日期:1997-09-22 00:00:00
abstract::CREB binding protein (CBP) is an acetyltransferase that plays an important role in many biological processes. Here, we show that Akt phosphorylates CBP at threonine 1871 and suppresses its acetyltransferase activity by impeding the binding of CBP to histone H3, which results in a decrease in lysine K18 acetylation and...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2013.02.023
更新日期:2013-04-02 00:00:00
abstract::The high cGMP sensitivity of cAMP-dependent protein kinase A (type II) (PKAII) from invertebrates led to the hypothesis that cGMP directly activates PKAII under physiological conditions. We tested this idea using PKAII holoenzyme purified from the honeybee brain in an assay with short stimulation times. In the presenc...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2004.08.079
更新日期:2004-10-08 00:00:00
abstract::The hexose transporter family of Saccharomyces cerevisiae comprises 18 proteins (Hxt1-17, Gal2). Here, we demonstrate that all these proteins, except Hxt12, and additionally three members of the maltose transporter family (Agt1, Ydl247, Yjr160) are able to transport hexoses. In a yeast strain deleted for HXT1-17, GAL2...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)01698-1
更新日期:1999-12-31 00:00:00
abstract::Hypermethylated in cancer, a new candidate tumor suppressor gene located in 17p13.3, encodes a protein with five Krüppel-like C2H2 zinc finger motifs and a N-terminal protein/protein interaction domain called broad complex, tramtrack and bric à brac/poxviruses and zinc finger domain. Hypermethylated in cancer appears ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)00583-9
更新日期:1999-05-28 00:00:00
abstract::The α-subunit of the cardiac voltage-gated sodium channel (NaV1.5) plays a central role in cardiomyocyte excitability. We have recently reported that NaV1.5 is post-translationally modified by arginine methylation. Here, we aimed to identify the enzymes that methylate NaV1.5, and to describe the role of arginine methy...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2013.07.043
更新日期:2013-10-01 00:00:00
abstract::DNA is very stable in its double-stranded form. For many processes of DNA metabolism, such as replication, repair, recombination and transcription, the DNA has to be brought transiently into a single-stranded form. DNA helicases are enzymes capable of melting the hydrogen bonds of base pairs by using the energy of nuc...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/0014-5793(90)81279-w
更新日期:1990-08-01 00:00:00
abstract::We describe the extraction and stabilization in vitro of discrete complexes of interferon and cellular receptor proteins. A homogeneous complex of Mr 230 000 was extracted at the time of peak receptor binding (30 min). Complex formation was specific for human interferon. At later times a second complex could also be e...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(83)80268-3
更新日期:1983-05-30 00:00:00
abstract::Polyinosinic-polycytidylic acid, a potent inducer of inducer of interferon (IFN) production and activator of some IFN-induced enzymes, inhibits [3H]uridine incorporation into the RNA of vesicular stomatitis virus even in the absence of IFN synthesis, transiently triggers the breakdown of inositol phospholipids and act...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(87)80541-0
更新日期:1987-12-21 00:00:00
abstract::The contribution of hepatic glycogen to lipogenesis was studied in isolated, intact rat hepatocytes. To establish its importance as a substrate for lipogenesis, the glycogen of isolated hepatocytes was prelabelled with 14C from glucose. Evidence is presented that neither glucose nor glycogen constitute major sources o...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(84)80558-x
更新日期:1984-09-17 00:00:00
abstract::We have reported that histone deacetylase (HDAC) inhibitors activate a member of the INK4 family, the p19INK4d gene, causing G1 phase arrest. We report here that HDAC inhibitor, Trichostatin A, activates another member of the INK4 family, the p18INK4c gene, through its promoter in Jurkat cells. Interestingly, the acti...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2004.08.025
更新日期:2004-09-10 00:00:00
abstract::Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha), a highly inducible transcriptional coactivator regulating energy homeostasis, is down-regulated in hepatoma tissues. To dissect its role in hepato-tumorigenesis, Ingenuity Pathway Analysis was applied to construct pathways affected by P...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2008.01.033
更新日期:2008-03-05 00:00:00
abstract::We have examined the activity of protein disulfide isomerase (PDI) and glutaredoxin (Grx) 1, 2 and 3 from Escherichia coli to catalyze the cleavage of glutathionylated ribonuclease A (RNase-SG) by 1 mM GSH to yield reduced RNase. Apparent Km values for RNase-SG were similar, 2-10 microM, for Grx 1, 3 and PDI but Grx I...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)01698-6
更新日期:1999-01-25 00:00:00
abstract::Myocyte stress 1 (MS1) is a recently described striated muscle actin-binding protein that is up-regulated in the early stages of pressure overload left ventricular hypertrophy. The aim of this study was to determine whether MS1 induces cellular hypertrophy and protects against apoptosis. Over-expressed MS1 co-localize...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2009.08.011
更新日期:2009-09-03 00:00:00
abstract::Heme is essential and synthesized via highly regulated processes. For this reason, most organisms strive to recycle it or acquire it from their environment. When heme is bound to proteins noncovalently, degradation of the polypeptide is sufficient to release it. However, in some hemoproteins, such as c-type cytochrome...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.13006
更新日期:2018-03-01 00:00:00