Abstract:
:Here, we investigated the molecular mechanism underlying the changes in the distribution of nucleolin. Our study identified PI3K/Akt signaling as an essential pathway regulating the distribution of nucleolin. Furthermore, nucleolin can interact with phospho-PI3K-p55, and changes in the distribution of nucleolin were related to its phosphorylation. Subsequently, we analyzed the correlation of VEGF and nucleolin, and found that distribution of nucleolin related to metastatic potential. Finally, blocking cell surface nucleolin influences the process of epithelial-mesenchymal transitions. This indicates that nucleolin may be a novel cancer therapy target and a predictive marker for tumor migration in colorectal carcinoma.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Wu DM,Zhang P,Liu RY,Sang YX,Zhou C,Xu GC,Yang JL,Tong AP,Wang CTdoi
10.1016/j.febslet.2014.03.047subject
Has Abstractpub_date
2014-05-21 00:00:00pages
1921-9issue
10eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00266-Xjournal_volume
588pub_type
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