Abstract:
:In lower and higher eukaryotes, a family of tightly related proteins designated eRF1 (for eukaryotic release factor 1) catalyses termination of protein synthesis at all three stop codons. The human genome contains four eRF1 homologous sequences localised on chromosomes 5, 6, 7 and X. We report here the cloning and the structural analysis of the human eRF1 gene family. It appears that the gene located on chromosome 5 alone is potentially functional, whereas the other three sequences resemble processed pseudogenes. This is the first description of the structural organisation of the human eRF1 gene, which has been remarkably conserved during evolution and which is essential in the translation termination process.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Guenet L,Toutain B,Guilleret I,Chauvel B,Deaven LL,Longmire JL,Le Gall JY,David V,Le Treut Adoi
10.1016/s0014-5793(99)00795-4keywords:
subject
Has Abstractpub_date
1999-07-02 00:00:00pages
131-6issue
1-2eissn
0014-5793issn
1873-3468pii
S0014-5793(99)00795-4journal_volume
454pub_type
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