Crystal structure of intracellular family 1 beta-glucosidase BGL1A from the basidiomycete Phanerochaete chrysosporium.

Abstract:

:The white-rot fungus Phanerochaete chrysosporium has two intracellular beta-glucosidases (BGL1A and BGL1B) belonging to glycoside hydrolase (GH) family 1. BGL1B effectively hydrolyzes cellobiose and cellobionolactone, but BGL1A does not. We have determined the crystal structure of BGL1A in substrate-free and gluconolactone complexed forms. The overall structure and the characteristic of subsite -1 (glycone site) were similar to those of other known GH1 enzymes. The loop regions covering on the (beta/alpha)(8) barrel was significantly deviated, and they form a unique subsite +1 (aglycone site) of BGL1A.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Nijikken Y,Tsukada T,Igarashi K,Samejima M,Wakagi T,Shoun H,Fushinobu S

doi

10.1016/j.febslet.2007.03.009

subject

Has Abstract

pub_date

2007-04-03 00:00:00

pages

1514-20

issue

7

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(07)00259-1

journal_volume

581

pub_type

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