Abstract:
:The present report provides evidence that, in A431 cells, interferon gamma (IFNgamma) induces the rapid (within 5 min), and reversible, tyrosine phosphorylation of the epidermal growth factor receptor (EGFR). IFNgamma-induced EGFR transactivation requires EGFR kinase activity, as well as activity of the Src-family tyrosine kinases and JAK2. Here, we show that IFNgamma-induced STAT1 activation in A431 and HeLa cells partially depends on the kinase activity of both EGFR and Src. Furthermore, in these cells, EGFR kinase activity is essential for IFNgamma-induced ERK1,2 activation. This study is the first to demonstrate that EGFR is implicated in IFNgamma-dependent signaling pathways.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Burova E,Vassilenko K,Dorosh V,Gonchar I,Nikolsky Ndoi
10.1016/j.febslet.2007.03.002subject
Has Abstractpub_date
2007-04-03 00:00:00pages
1475-80issue
7eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00251-7journal_volume
581pub_type
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