Abstract:
:Physiological and pathological states that are associated with elevated plasma fatty acids (FAs) increase uncoupling protein 2 (UCP2) mRNA in white adipose tissue and UCP3 mRNA in skeletal muscle and heart. A direct effect of unsaturated fatty acids from all classes has been shown in various cultured cells. There is evidence that FAs could induce expression of UCPs by acting as ligands for peroxisome proliferator-activated receptors, influencing the function of sterol responsive element binding protein or activating 5'-AMP-activated protein kinase. Oleic acid has been shown to stimulate the activity of the promoter regions of UCP2 and UCP3 genes and the FA responsive regions are beginning to be characterised.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Thompson MP,Kim Ddoi
10.1016/j.febslet.2004.05.011keywords:
subject
Has Abstractpub_date
2004-06-18 00:00:00pages
4-9issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579304006167journal_volume
568pub_type
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