Abstract:
:Human Tudor staphylococcal nuclease (Tudor-SN) interacts with the G3BP protein and is recruited into stress granules (SGs), the main type of discrete RNA-containing cytoplasmic foci structure that is formed under stress conditions. Here, we further demonstrate that Tudor-SN binds and co-localizes with AGTR1-3'UTR (3'-untranslated region of angiotensin II receptor, type 1 mRNA) into SG. Tudor-SN plays an important role in the assembly of AGTR1-3'UTR granules. Moreover, endogenous Tudor-SN knockdown can decrease the recovery kinetics of AGTR1-3'UTR granules. Collectively, our data indicate that Tudor-SN modulates the kinetics of AGTR1-3'UTR granule formation, which provides an additional biological role of Tudor-SN in RNA metabolism during stress.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gao X,Shi X,Fu X,Ge L,Zhang Y,Su C,Yang X,Silvennoinen O,Yao Z,He J,Wei M,Yang Jdoi
10.1016/j.febslet.2014.04.045subject
Has Abstractpub_date
2014-06-13 00:00:00pages
2154-61issue
13eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00331-7journal_volume
588pub_type
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