Abstract:
:The purinergic P2X(7) receptor is an ATP-receptor channel predominantly expressed in immune cells. P2X(7) has been cloned from human, rat and mouse. Here we report cloning of the Xenopus laevis P2X(7) receptor (xP2X(7)). xP2X(7) is only about 50% identical to the mammalian homologues, shows a broad tissue expression pattern, and has the electrophysiological characteristics typical of a P2X(7) receptor: low agonist affinity (EC(50) about 2.6 mM) and a non-desensitizing current. Moreover, expression of xP2X(7) in Xenopus oocytes is sufficient to induce the formation of a large pore, which is permeable to large cations such as NMDG(+). Identification of a non-mammalian P2X(7) receptor may help to identify functionally important parts of the protein.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Paukert M,Hidayat S,Gründer Sdoi
10.1016/s0014-5793(02)02324-4keywords:
subject
Has Abstractpub_date
2002-02-27 00:00:00pages
253-8issue
2-3eissn
0014-5793issn
1873-3468pii
S0014579302023244journal_volume
513pub_type
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