Abstract:
:All the known members of the mouse Notch receptor family were examined for their biochemical function by interaction with a DNA binding protein RBP-Jkappa. mNotch2, mNotch3 and int3 (= mNotch4) were shown to interact with RBP-Jkappa by the GST-fusion pull down assay and dominant negative competition with Epstein Barr virus nuclear antigen 2. Furthermore the intracellular region of int3 was shown to transactivate the Epstein Barr virus TP1 promoter. These results indicate that all mouse Notch family members have biochemical functions similar to mNotch1, which transduces proliferative signal by direct interaction with the DNA binding protein RBP-Jkappa.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kato H,Sakai T,Tamura K,Minoguchi S,Shirayoshi Y,Hamada Y,Tsujimoto Y,Honjo Tdoi
10.1016/0014-5793(96)01046-0subject
Has Abstractpub_date
1996-10-21 00:00:00pages
221-4issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(96)01046-0journal_volume
395pub_type
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