Abstract:
:Frame shift mutations of the polyglutamine binding protein-1 (PQBP1) gene lead to total or partial truncation of the C-terminal domain (CTD) and cause mental retardation in human patients. Interestingly, normal Drosophila homologue of PQBP-1 lacks CTD. As a model to analyze the molecular network of PQBP-1 affecting intelligence, we generated transgenic flies expressing human PQBP-1 with CTD. Pavlovian olfactory conditioning revealed that the transgenic flies showed disturbance of long-term memory. In addition, they showed abnormal courtship that male flies follow male flies. Abnormal functions of PQBP-1 or its binding partner might be linked to these symptoms.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Yoshimura N,Horiuchi D,Shibata M,Saitoe M,Qi ML,Okazawa Hdoi
10.1016/j.febslet.2006.03.056subject
Has Abstractpub_date
2006-04-17 00:00:00pages
2335-40issue
9eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00371-1journal_volume
580pub_type
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