Abstract:
:Kaempferol is a dietary flavonoid that is thought to function as a selective estrogen receptor modulator. In this study, we established that kaempferol also functions as an inverse agonist for estrogen-related receptors alpha and gamma (ERRalpha and ERRgamma). We demonstrated that kaempferol binds to ERRalpha and ERRgamma and blocks their interaction with coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha). Kaempferol also suppressed the expressions of ERR-target genes pyruvate dehydrogenase kinase 2 and 4 (PDK2 and PDK4). This evidence suggests that kaempferol may exert some of its biological effect through both estrogen receptors and estrogen-related receptors.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Wang J,Fang F,Huang Z,Wang Y,Wong Cdoi
10.1016/j.febslet.2009.01.030subject
Has Abstractpub_date
2009-02-18 00:00:00pages
643-7issue
4eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00048-9journal_volume
583pub_type
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