Abstract:
:In Xenopus prophase-blocked oocytes, it is assumed that progesterone interacts with the plasma membrane to initiate a signalling cascade that ultimately leads to MPF activation. Progesterone regulates negatively the cAMP pathway through an inhibition of adenylate cyclase. However, the mechanisms linking the initial action of the hormone with adenylate cyclase activity remain to be elucidated. Here, we demonstrate that PDMP, an inhibitor of glucosphingolipid synthesis, triggers oocyte meiotic maturation in a cAMP- and cycloheximide-dependent manner, whereas exogenous ceramide is unefficient. We propose that sphingolipid metabolism and targeting represent an important regulatory process of oocyte meiosis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
De Smedt V,Rime H,Jessus C,Ozon Rdoi
10.1016/0014-5793(95)01183-fsubject
Has Abstractpub_date
1995-11-20 00:00:00pages
249-53issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(95)01183-Fjournal_volume
375pub_type
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