Abstract:
:Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress. The ER stress sensor inositol requiring enzyme-1beta (IRE1β), which is specifically expressed in intestinal epithelial cells, is thought to be involved in translational repression. However, its mechanism of action is not fully understood. Using a reporter that can evaluate and distinguish between translation efficiency in the cytosol and on the ER membrane, we show here that IRE1β represses translation on the ER membrane but not in the cytosol, and that this selective repression depends on the RNase activity of IRE1β.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nakamura D,Tsuru A,Ikegami K,Imagawa Y,Fujimoto N,Kohno Kdoi
10.1016/j.febslet.2010.12.002subject
Has Abstractpub_date
2011-01-03 00:00:00pages
133-8issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00987-7journal_volume
585pub_type
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