Abstract:
:Recently mutations in the LGI1 (leucine-rich, glioma-inactivated 1) gene have been found in human temporal lobe epilepsy. We have now identified three formerly unknown LGI-like genes. Hydropathy plots and pattern analysis showed that LGI genes encode proteins with large extra- and intracellular domains connected by a single transmembrane region. Sequence analysis demonstrated that LGI1, LGI2, LGI3, and LGI4 form a distinct subfamily when compared to other leucine-rich repeat-containing proteins. In silico mapping and radiation hybrid experiments assigned LGI2, LGI3, and LGI4 to different chromosomal regions (4p15.2, 8p21.3, 19q13.11), some of which have been implicated in epileptogenesis and/or tumorigenesis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gu W,Wevers A,Schröder H,Grzeschik KH,Derst C,Brodtkorb E,de Vos R,Steinlein OKdoi
10.1016/s0014-5793(02)02713-8keywords:
subject
Has Abstractpub_date
2002-05-22 00:00:00pages
71-6issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579302027138journal_volume
519pub_type
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