IL-2-induced gene expression of protein-tyrosine phosphatase LC-PTP requires acidic and serine-rich regions within IL-2 receptor beta chain.

abstract：:Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known to act as a lipid phosphatase hydrolyzing phosphatidylinositol (PI)(3,4,5)P(3) to PI(4,5)P(2). Since the PI3-kinase product, PI(3,4,5)P(3), is an important second messenger leading to the metabolic action of insulin, PTEN functions as a potent neg...

journal_title：FEBS letters

authors： Ishihara H,Sasaoka T,Kagawa S,Murakami S,Fukui K,Kawagishi Y,Yamazaki K,Sato A,Iwata M,Urakaze M,Ishiki M,Wada T,Yaguchi S,Tsuneki H,Kimura I,Kobayashi M

更新日期：2003-11-20 00:00:00

abstract：:Differentiation of glia (astrocytes and oligodendrocytes) in Drosophila requires the gene glial cells missing (gcm), which controls lineage determination. In the absence of gcm, neuroglia progenitors exclusively differentiate into neurons, instead of into both neurons and glia. In contrast, ectopic overexpression of g...

journal_title：FEBS letters

authors： Altshuller Y,Copeland NG,Gilbert DJ,Jenkins NA,Frohman MA

更新日期：1996-09-16 00:00:00

abstract：:Using antibodies recognizing the phosphorylation state of specific sites, phosphorylation states of tau were monitored in fetal rat primary cultured neurons. When cultured neurons were treated with okadaic acid (OA) or calyculin A (CalA) at concentrations sufficient to inhibit protein phosphatase 2A (PP2A), phosphoryl...

journal_title：FEBS letters

authors： Saito T,Ishiguro K,Uchida T,Miyamoto E,Kishimoto T,Hisanaga S

更新日期：1995-12-04 00:00:00

abstract：:Dendritic cells (DCs) are known to modulate immune response by activating effector cells of both the innate and the adaptive immune system. In the present study, we demonstrate that co-culture of DCs with paraformaldehyde-fixed tumor cells augments the secretion of interleukin (IL)-12 by DCs and these activated DCs up...

journal_title：FEBS letters

authors： Alli RS,Khar A

更新日期：2004-02-13 00:00:00

abstract：:Protein D2 forms the water-filled pore across the outer membrane of Pseudomonas aeruginosa and allows the penetration of imipenem. We cloned the protein D2 gene by the antibody screening technique. When the imipenem-resistant mutant lacking protein D2 harbored the plasmid with the cloned D2 gene, the mutant overproduc...

journal_title：FEBS letters

authors： Yoneyama H,Nakae T

更新日期：1991-06-03 00:00:00

abstract：:The nervous and immune systems have similar functional characteristics. Both have an intricate network of synaptic connections and an exquisite communication system that enable intercellular signal transduction. Although semaphorins were originally identified as guidance cues in neural development, accumulating eviden...

journal_title：FEBS letters

authors： Okuno T,Nakatsuji Y,Kumanogoh A

更新日期：2011-12-01 00:00:00

abstract：:Pasteurella multocida toxin is a potent mitogen for cultured Swiss 3T3 cells where it causes an accumulation of inositol phosphates and activation of protein kinase C. The gene sequence described here coded for a 146 kDa protein. The ORF was preceded by a ribosome binding site and followed by a stem loop. There was no...

journal_title：FEBS letters

authors： Lax AJ,Chanter N,Pullinger GD,Higgins T,Staddon JM,Rozengurt E

更新日期：1990-12-17 00:00:00

abstract：:We have studied the pharmacological properties of genetically engineered human NK1 tachykinin receptors in which residues at the extracellular surface of the fourth transmembranal domain were substituted with the corresponding amino acids from the NK2 receptor. We show that substitution of G166C:Y167F in the human NK1...

journal_title：FEBS letters

authors： Ciucci A,Palma C,Riitano D,Manzini S,Werge TM

更新日期：1997-10-27 00:00:00

abstract：:Polysulfide is a bound sulfur species derived from endogenous H2S. When mouse neuroblastoma, Neuro2A cells were exposed to tert-butyl hydroperoxide after treatment with polysulfide, a significant decline in cell toxicity was observed. Rapid uptake of polysulfides induced translocation of Nrf2 into the nucleus, resulti...

journal_title：FEBS letters

authors： Koike S,Ogasawara Y,Shibuya N,Kimura H,Ishii K

更新日期：2013-11-01 00:00:00

abstract：:The uncoupler-induced inactivation of H+-ATPase in hepatoma 22a and mouse liver mitochondria has been studied. The dependence of this process on delta microH, and pH and ATP was established. The inactivated ATPase could be reactivated at alkaline pH values in the absence of ATP. These data indicate that the inactivati...

journal_title：FEBS letters

authors： Chernyak BV,Dukhovich VF,Khodjaev EYu

更新日期：1987-05-11 00:00:00

abstract：:In mouse mammary epithelial cells in primary culture, mechanical stimulation of a cell induced in other cells within the same colony a short depolarization of less than 15 mV with a duration of 1-8 s and a subsequent, prominent hyperpolarization of 6 mV lasting 10-40 s. Epidermal growth factor induces a spontaneous hy...

journal_title：FEBS letters

authors： Enomoto K,Furuya K,Maeno T,Edwards C,Oka T

更新日期：1987-10-19 00:00:00

abstract：:To identify the linear epitope for Fc-binding on the bovine IgG2 Fc receptor (boFcgamma2R), peptides derived from the membrane-distal extracellular domain (EC1) of boFcgamma2R corresponding to the homologous region of human FcalphaRI were synthesized. Binding of bovine IgG2 to the different peptides was tested by Dot-...

journal_title：FEBS letters

authors： Zhang G,Guo J,Zhou J,Wang X,Li Q,Yang Y,Shen H,Zhao D,Zhang H,Xi J,Wang L,Qiao S,Jin X

更新日期：2006-02-20 00:00:00

abstract：:Previous data have suggested an involvement of MDR/PGP-like ABC transporters in transport of the plant hormone auxin and, recently, AtPGP1 has been demonstrated to catalyze the primary active export of auxin. Here we show that related isoform AtPGP4 is expressed predominantly during early root development. AtPGP4 loss...

journal_title：FEBS letters

authors： Santelia D,Vincenzetti V,Azzarello E,Bovet L,Fukao Y,Düchtig P,Mancuso S,Martinoia E,Geisler M

更新日期：2005-10-10 00:00:00

abstract：:Magnesium (Mg(2+)) transport across membranes plays an essential role in cellular growth and survival. TRPM7 is the unique fusion of a Mg(2+) permeable pore with an active cytosolic kinase domain, and is considered a master regulator of cellular Mg(2+) homeostasis. We previously found that the genetic deletion of TRPM...

journal_title：FEBS letters

authors： Deason-Towne F,Perraud AL,Schmitz C

更新日期：2011-07-21 00:00:00

abstract：:Accumulating evidence has indicated that microRNAs (miRNAs) act as critical epigenetic regulators in tumor carcinogenesis. Here, we report that miR-199a-3p was significantly upregulated in gastric cancer (GC) cell lines and tissues. Functional studies demonstrated that miR-199a-3p dramatically increased cell prolifera...

journal_title：FEBS letters

authors： Wang Z,Ma X,Cai Q,Wang X,Yu B,Cai Q,liu B,Zhu Z,Li C

更新日期：2014-11-28 00:00:00

abstract：:Calcium channels derived from sarcoplasmic reticulum of frog skeletal muscle were fused with planar lipid bilayers. Fractional open times displayed two types of calcium dependence: (i) blockable channels showed a bell-shaped calcium dependence with an activation constant of 4.5 microM, a Hill coefficient for activatio...

journal_title：FEBS letters

authors： Bull R,Marengo JJ

更新日期：1993-10-04 00:00:00

abstract：:We have isolated a full-size cDNA coding for cardiac troponin T (cTnT) from a human adult heart library, using a slow skeletal TnT probe. This cDNA detected a 1.2 kb mRNA in fetal and post-natal human heart, the amount of which increased during ontogenic development. Interestingly, a similar transcript was coexpressed...

journal_title：FEBS letters

authors： Mesnard L,Samson F,Espinasse I,Durand J,Neveux JY,Mercadier JJ

更新日期：1993-08-09 00:00:00

abstract：:6-Phosphofructo-2-kinase catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, activator of phosphofructokinase-1 and inhibitor of fructose 1,6-bisphosphatase. These properties confer to this bifunctional enzyme a key role in the control of glycolysis and gluconeogenesis. Several mammalian isozymes gen...

journal_title：FEBS letters

authors： Riera L,Obach M,Navarro-Sabaté A,Duran J,Perales JC,Viñals F,Rosa JL,Ventura F,Bartrons R

更新日期：2003-08-28 00:00:00

abstract：:The lactase-phlorizin hydrolase gene was assigned to chromosome 2 by analysis of Southern blots of DNA from a panel of human-rodent cell hybrids containing characteristic sets of human chromosomes The hybridization probe used was a recently isolated cDNA clone of the human lactase-phlorizin hydrolase gene. ...

journal_title：FEBS letters

authors： Kruse TA,Bolund L,Grzeschik KH,Ropers HH,Sjöström H,Norén O,Mantei N,Semenza G

更新日期：1988-11-21 00:00:00

abstract：:Muscle phosphofructokinase interacts with microtubule-associated protein-free microtubules resulting in a reduction of the overall activity of the enzyme [Lehotzky et al. (1993) J. Biol. Chem. 268, 10888-10894] and periodical cross-linking of the tubules [Lehotzky et al. (1994) Biochem. Biophys. Res. Commun. 204, 585-...

journal_title：FEBS letters

authors： Vértessy BG,Kovács J,Ovádi J

更新日期：1996-01-29 00:00:00

abstract：:Activity of the plant mitochondrial alternative oxidase (AOX) can be regulated by organic acids, notably pyruvate. To date, only two well-conserved cysteine residues have been implicated in this process. We report the functional expression of two AOX isozymes (Sauromatum guttatum Sg-AOX and Arabidopsis thaliana At-AOX...

journal_title：FEBS letters

authors： Crichton PG,Affourtit C,Albury MS,Carré JE,Moore AL

更新日期：2005-01-17 00:00:00

abstract：:Caloric restriction (CR) is known to promote longevity in various species. Sirtuin-mediated deacetylation has been shown to be related to the promotion of longevity in some species. Here, we show that CR of rats led to an increase in the level of Werner syndrome protein (WRN), a recognized DNA repair protein. In addit...

journal_title：FEBS letters

authors： Kahyo T,Mostoslavsky R,Goto M,Setou M

更新日期：2008-07-23 00:00:00

abstract：:We previously described that NO. leads to destruction of ZnS clusters and release of Zn2+ from various proteins including zinc finger transcription factors. To assess the relevance in living cells, we investigated, whether exogenous NO. leads to an increase of cytoplasmic and nuclear free Zn2+. L929 cells, mouse splen...

journal_title：FEBS letters

authors： Berendji D,Kolb-Bachofen V,Meyer KL,Grapenthin O,Weber H,Wahn V,Kröncke KD

更新日期：1997-03-17 00:00:00

abstract：:Structure/function relationships in troponin C are studied with vertebrate fast-twitch fibers by exchanging the skeletal troponin C with two bacterially synthesized recombinant proteins designed by site-directed mutagenesis of cardiac troponin C. One mutant (CBM1) contained an additional active site, by deleting Val-2...

journal_title：FEBS letters

authors： Gulati J,Babu A,Putkey JA

更新日期：1989-05-08 00:00:00

abstract：:Atrial natriuretic factor (ANF) and C-type natriuretic peptide (CNP)-activated guanylate cyclases are single-chain transmembrane-spanning proteins, containing both ligand binding and catalytic activities. In both proteins, ligand binding to the extracellular receptor domain activates the cytosolic catalytic domain, ge...

journal_title：FEBS letters

authors： Duda T,Goraczniak RM,Sharma RK

更新日期：1993-12-13 00:00:00

abstract：:Proteins containing the caspase recruiting domain (CARD) have emerged as critical regulators of different signal transduction pathways, including those controlling apoptosis and activation of necrosis factor (NF)-kappaB transcription factor. TUCAN/CARDINAL is a recently identified CARD-containing protein involved in r...

journal_title：FEBS letters

authors： Stilo R,Leonardi A,Formisano L,Di Jeso B,Vito P,Liguoro D

更新日期：2002-06-19 00:00:00

abstract：:The present one-drug-one-target paradigm in drug discovery has been considered partially responsible for the more-funding-less-drug predicament in modern pharmaceutical industry. To hit the multiple targets implicated in complex diseases, two strategies, based on multicomponent or single-ingredient, are conceivable. A...

journal_title：FEBS letters

authors： Zhang HY

更新日期：2005-10-10 00:00:00

abstract：:Several clinical studies have shown that cyclosporin A (CsA) is effective for treating a variety of chronic inflammatory and autoimmune diseases. Because reactive oxygen species are believed to play a key role in the development of these diseases, causing cell apoptosis, we investigated whether CsA inhibits H2O2-induc...

journal_title：FEBS letters

authors： Sugano N,Ito K,Murai S

更新日期：1999-03-26 00:00:00

abstract：:Stopped-flow kinetics showed that the inhibition of the lysosomal cysteine proteinase, cathepsin B, by its endogenous inhibitor, cystatin C, occurs by a two-step mechanism, in which an initial, weak interaction is followed by a conformational change. The initial interaction most likely involves binding of the N-termin...

journal_title：FEBS letters

authors： Nycander M,Estrada S,Mort JS,Abrahamson M,Björk I

更新日期：1998-01-23 00:00:00

abstract：:The contribution of hepatic glycogen to lipogenesis was studied in isolated, intact rat hepatocytes. To establish its importance as a substrate for lipogenesis, the glycogen of isolated hepatocytes was prelabelled with 14C from glucose. Evidence is presented that neither glucose nor glycogen constitute major sources o...

journal_title：FEBS letters

authors： Geelen MJ,Hindriks GA

更新日期：1984-09-17 00:00:00