Gcm1, a mammalian homolog of Drosophila glial cells missing.

abstract：:Okadaic acid is an inhibitor of the protein Ser/Thr phosphatases PP1 and PP2A, which blocks the activation of extracellular signal-regulated protein kinase 5 (ERK5), a member of the MAP kinase family activated by growth factors and several types of stressors. The blocking of ERK5 activation by okadaic acid was observe...

journal_title：FEBS letters

authors： Garcia L,Garcia F,Llorens F,Unzeta M,Itarte E,Gómez N

更新日期：2002-07-17 00:00:00

abstract：:We report a rapid and sensitive colorimetric approach to quantitate the amount of glucose transporters exposed at the surface of intact cells, using L6 muscle cells expressing GLUT4 containing an exofacial myc epitope. Unstimulated cells exposed to the surface 5 fmol GLUT4myc per mg protein. This value increased to 10...

journal_title：FEBS letters

authors： Wang Q,Khayat Z,Kishi K,Ebina Y,Klip A

更新日期：1998-05-08 00:00:00

abstract：:Lysophosphatidic acid (LPA) exerts multiple biological functions through G protein-coupled receptors (EDG2/LPA(1), EDG4/LPA(2), and EDG7/LPA(3)) and is present in serum where it is associated with albumin. In this study we examined LPA activity in various biological fluids by measuring the LPA-induced increase in the ...

journal_title：FEBS letters

authors： Hama K,Bandoh K,Kakehi Y,Aoki J,Arai H

更新日期：2002-07-17 00:00:00

abstract：:6-Photocholesterol, a new photoactivatable analog of cholesterol in which a diazirine functionality replaces the 5,6-double bond in the steroid nucleus, was used recently to identify cholesterol-binding proteins in neuroendocrine cells [Thiele, C., Hannah, M.J., Farenholz, F. and Huttner, W.B. (2000) Nat. Cell Biol. 2...

journal_title：FEBS letters

authors： Mintzer EA,Waarts BL,Wilschut J,Bittman R

更新日期：2002-01-16 00:00:00

abstract：:The presence of protein kinase C (PKC), a key enzyme in signal transduction, has not been investigated in fungal cells. The phorbol ester TPA, an activator of PKC, may be used as an indicator of the presence and role of PKC in Phycomyces blakesleeanus spores. Activation of spore germination by acetate was prevented by...

journal_title：FEBS letters

authors： Carrillo-Rayas T,Garcia-Soto J,Martinez-Cadena G

更新日期：1988-10-10 00:00:00

abstract：:Stresses that impair the function of the endoplasmic reticulum (ER) lead to an accumulation of unfolded protein in the ER. Under these conditions, the expression of a variety of genes involved in preventing the accumulation of the unfolded proteins is induced. Yeast Hrd1p is an ER stress-inducible ER membrane protein ...

journal_title：FEBS letters

authors： Kaneko M,Ishiguro M,Niinuma Y,Uesugi M,Nomura Y

更新日期：2002-12-04 00:00:00

abstract：:Inducible nitric oxide (NO) synthase (iNOS) appears to be a marker of tumor progression in colon carcinogenesis. Here we investigated effects of NO on selected chemokines that differentially regulate angiogenesis, namely pro-angiogenic interleukin (IL)-8 as well as tumor-suppressive interferon-inducible protein-10 (IP...

journal_title：FEBS letters

authors： Hellmuth M,Paulukat J,Ninic R,Pfeilschifter J,Mühl H

更新日期：2004-04-09 00:00:00

abstract：:A pronounced transitory increase of histone acetyltransferase (EC 2.3.1.48) activity before the onset of DNA replication is shown to occur in regenerating rat liver. This effect is followed by an increase in the H1/H1(0) ratio at the start of DNA synthesis; H1(0) de is replaced by H1. Histone acetylation and H1/H1(0) ...

journal_title：FEBS letters

authors： Weiss G,Puschendorf B

更新日期：1988-09-26 00:00:00

abstract：:A new abnormal hemoglobin, Hb Mito [beta 144(HC 1) Lys----Glu], with an amino acid substitution in the 2,3-DPG pocket, was discovered in a Japanese female. This hemoglobin showed increased oxygen affinity, and decreased organic phosphate and Bohr effects, while the Hill constant n was normal. ...

journal_title：FEBS letters

authors： Harano K,Harano T,Ueda S,Ohkushi T,Imai K

更新日期：1985-11-11 00:00:00

abstract：:MicroRNA-107 (miR-107) has been demonstrated to regulate proliferation and apoptosis in many types of cancers. Nevertheless, its biological function in gastric cancer remains largely unexplored. Here, we found that the expression level of miR-107 was increased in gastric cancer in comparison with the adjacent normal t...

journal_title：FEBS letters

authors： Li F,Liu B,Gao Y,Liu Y,Xu Y,Tong W,Zhang A

更新日期：2014-02-14 00:00:00

abstract：:The phytocannabinoid Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), the main psychoactive cannabinoid in cannabis, activates a number of signalling cascades including p53. This study examines the role of Delta(9)-THC in regulating the p53 post-translational modifier proteins, Murine double minute (Mdm2) and Small Ubqui...

journal_title：FEBS letters

authors： Gowran A,Murphy CE,Campbell VA

更新日期：2009-11-03 00:00:00

abstract：:WT1 was isolated as a tumor suppressor gene of Wilms tumor. However, high expression of WT1 correlates with poor prognosis in acute leukemia. In addition suppression of WT1 expression by WT1 anti-sense oligonucleotide inhibits proliferation of leukemia cells, suggesting that WT1 is important for their proliferation. T...

journal_title：FEBS letters

authors： Murata Y,Kudoh T,Sugiyama H,Toyoshima K,Akiyama T

更新日期：1997-06-02 00:00:00

abstract：:The nucleotide sequence of cDNA encoding the human substance P precursor, beta-preprotachykinin (beta-PPT), has been determined. The source of mRNA was a human laryngeal carcinoid tumour that contained a high concentration of immunoreactive substance P. The human beta-PPT polypeptide is 129 amino acids long and contai...

journal_title：FEBS letters

authors： Harmar AJ,Armstrong A,Pascall JC,Chapman K,Rosie R,Curtis A,Going J,Edwards CR,Fink G

更新日期：1986-11-10 00:00:00

abstract：:The entire structure of a 98 kb genomic region that abounds in genes related to magnetosome synthesis was first described in the Magnetospirillum sp. strain AMB-1. The deletion of this 98 kb genomic region and the circular form after excision from the chromosome was detected by PCR amplification. This strongly suggest...

journal_title：FEBS letters

authors： Fukuda Y,Okamura Y,Takeyama H,Matsunaga T

更新日期：2006-02-06 00:00:00

abstract：:In contrast to the preponderance of affected males in families with X-linked mental retardation, Rett syndrome (RTT) is a neurological disorder occurring almost exclusively in females. The near complete absence of affected males in RTT families has been explained by the lethal effect of an X-linked gene mutation in he...

journal_title：FEBS letters

authors： Orrico A,Lam C,Galli L,Dotti MT,Hayek G,Tong SF,Poon PM,Zappella M,Federico A,Sorrentino V

更新日期：2000-09-22 00:00:00

abstract：:A full-length cDNA clone (RASC8) encoding glutaredoxin (thioltransferase) was isolated from a cDNA library of an aleurone layer prepared from a developing seed of rice (Oryza sativa L.). RASC8, 568bp in length, contained an ATG codon and two possible polyadenylation signals, and encoded 112 amino acid residues. Cys-Pr...

journal_title：FEBS letters

authors： Minakuchi K,Yabushita T,Masumura T,Ichihara K,Tanaka K

更新日期：1994-01-10 00:00:00

abstract：:Transient receptor potential (TRP) proteins are sensory-related cation channels. TRPV subfamily responds to vanilloids, generating a Ca(2+) current. TRPV1, a thermal-sensitive non-selective ion channel, possesses six transmembrane helices and the intracellular N- and C-terminal domains. The latter contains the PIP(2) ...

journal_title：FEBS letters

authors： Aguado-Llera D,Bacarizo J,Gregorio-Teruel L,Taberner FJ,Cámara-Artigas A,Neira JL

更新日期：2012-04-24 00:00:00

abstract：:Gp130 is the common signal transducing receptor subunit of interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor and cardiotrophin-1. IL-6 and IL-11 induce gp130 homodimerization whereas the others lead to the formation of heterodimers with LIFR or OSMR. Binding e...

journal_title：FEBS letters

authors： Timmermann A,Pflanz S,Grötzinger J,Küster A,Kurth I,Pitard V,Heinrich PC,Müller-Newen G

更新日期：2000-02-25 00:00:00

abstract：:In this study, functional proteomics was successfully applied for the characterization of circadian expressed, basic proteins. For this purpose, we have chosen the green model alga Chlamydomonas reinhardtii since its entire nuclear genome is available and it is ideally suited for biochemical enrichment procedures. Pro...

journal_title：FEBS letters

authors： Wagner V,Fiedler M,Markert C,Hippler M,Mittag M

更新日期：2004-02-13 00:00:00

abstract：:A covalent complex formed by bacterial tRNAs and prothymosin alpha, an abundant acidic nuclear protein involved in proliferation of mammalian cells, upon production of the recombinant rat protein in Escherichia coli cells was studied. Several tRNA attachment sites were identified in the prothymosin alpha molecule usin...

journal_title：FEBS letters

authors： Lukashev DE,Chichkova NV,Vartapetian AB

更新日期：1999-05-21 00:00:00

abstract：:The odorant-induced accumulation of cAMP can be inhibited by antibodies directed against G alpha s/olf. In contrast, antibodies raised against G alpha i-subunits caused a strong enhancement of the odorant-induced cAMP accumulation. Western blotting and immunoelectron microscopy revealed the presence of both G alpha s/...

journal_title：FEBS letters

authors： Sinnarajah S,Ezeh PI,Pathirana S,Moss AG,Morrison EE,Vodyanoy V

更新日期：1998-04-24 00:00:00

abstract：:JAK2 V617F mutant induces transformation through aberrant activation of various transcription factors. We found that the expression of Aurora kinase A (Aurka) was significantly induced by mutant JAK2 through c-Myc expression. Interestingly, mutant JAK2 enhanced resistance to cisplatin (CDDP)-induced DNA damage, and ef...

journal_title：FEBS letters

authors： Sumi K,Tago K,Kasahara T,Funakoshi-Tago M

更新日期：2011-06-23 00:00:00

abstract：:The sarcoplasmic reticulum Ca(2+)-ATPase loses hydrolytic activity and the ability to be phosphorylated by Pi following incubation with EDC [1-ethyl-3-(3-dimethylaminopropyl)carbodiimide]. 4 nmol of tempamine per mg SR protein can be coupled to either a glu or an asp side chain through the EDC reaction. Mg2+ protects ...

journal_title：FEBS letters

authors： Coan C,Jakobs P,Ji JY,Murphy AJ

更新日期：1993-11-29 00:00:00

abstract：:IRF-8/ICSBP and IRF-1 are IRF family members whose expression is induced in response to IFN-gamma in macrophages. IL-12 is a cytokine produced in macrophages that plays a critical role in host defense. IFN-gamma and bacterial lipopolysaccharide (LPS) induce IL-12p40 transcription, which is necessary for the production...

journal_title：FEBS letters

authors： Masumi A,Tamaoki S,Wang IM,Ozato K,Komuro K

更新日期：2002-11-06 00:00:00

abstract：:Spermidine N1-acetyltransferase in an extract from phytohemagglutinin-stimulated bovine lymphocytes was inactivated by preincubation with alkaline phosphatase. Inactivation of the acetylase with the phosphatase was totally inhibited by addition of pyrophosphate. These results suggest that spermidine N1-acetyltransfera...

journal_title：FEBS letters

authors： Matsui I,Otani S,Kamei M,Morisawa S

更新日期：1982-12-13 00:00:00

abstract：:In this paper we introduce monobromobimane, a thiol reagent, as a selective blocker of the recently identified dithiol whose oxidation-reduction status modifies voltage sensing by the mitochondrial permeability transition pore, a cyclosporin A-sensitive channel. Monobromobimane does not inhibit the phosphate carrier, ...

journal_title：FEBS letters

authors： Costantini P,Chernyak BV,Petronilli V,Bernardi P

更新日期：1995-04-03 00:00:00

abstract：:The present one-drug-one-target paradigm in drug discovery has been considered partially responsible for the more-funding-less-drug predicament in modern pharmaceutical industry. To hit the multiple targets implicated in complex diseases, two strategies, based on multicomponent or single-ingredient, are conceivable. A...

journal_title：FEBS letters

authors： Zhang HY

更新日期：2005-10-10 00:00:00

abstract：:To identify genes whose expression is modulated by heregulin-beta1 (HRG), a regulatory polypeptide for mammary epithelial cells, we performed differential display screening of MCF-7 cell mRNA. One cDNA clone upregulated by HRG was identical to human ADP-ribosylation factor 3 (ARF3), a guanine nucleotide-binding protei...

journal_title：FEBS letters

authors： Li F,Mandal M,Mishra SK,Barnes CJ,Kumar R

更新日期：2002-07-31 00:00:00

abstract：:Early results showed the emanation of chromatin fibers from mitotic chromosomes and nuclei swollen with water. In contrast, under metaphase ionic conditions, it was found that chromatin from mitotic chromosomes is planar and forms multilayered plates. Here, we show that in buffers containing interphase cation concentr...

journal_title：FEBS letters

authors： Chicano A,Daban JR

更新日期：2019-04-01 00:00:00

abstract：:It was found for RNases of different specificities that changes in the free energy for substrate-enzyme binding induced by variations in the nucleotide base structure are accompanied by proportional changes in kcat/Km. This was considered to be a consequence of the strain in the enzyme-substrate complex. ...

journal_title：FEBS letters

authors： Yakovlev GI,Bocharov AL,Moiseyev GP

更新日期：1984-10-01 00:00:00