Abstract:
:Proteins containing the caspase recruiting domain (CARD) have emerged as critical regulators of different signal transduction pathways, including those controlling apoptosis and activation of necrosis factor (NF)-kappaB transcription factor. TUCAN/CARDINAL is a recently identified CARD-containing protein involved in regulation of caspases and NF-kappaB activation. We find that TUCAN/CARDINAL associates with DRAL, a p53-responsive gene implicated in induction of apoptosis. We also show that, whereas TUCAN/CARDINAL exerts a suppressive effect on NF-kappaB activity, expression of DRAL results in enhancement of NF-kappaB activation. Thus, our observations suggest that DRAL and TUCAN/CARDINAL may participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappaB transcription factor.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Stilo R,Leonardi A,Formisano L,Di Jeso B,Vito P,Liguoro Ddoi
10.1016/s0014-5793(02)02869-7keywords:
subject
Has Abstractpub_date
2002-06-19 00:00:00pages
165-9issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579302028697journal_volume
521pub_type
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