Abstract:
:Monoclonal antibodies (mAbs) against cell surface antigens and receptors are instrumental in defining specific membrane markers. mAbs GF 26.7.3 and MF 25.1 against human neutrophils modulated the activation mechanism of superoxide anion production induced by formyl-peptide and PMA in all subject. However, treatment with mAb MF 25.1 of neutrophils from patients with rheumatoid arthritis did not have any effect. This may suggest that the antigen which MF 25.1 binds is absent in rheumatoid conditions. This confirms our previous data showing that defective expression of membrane components is associated with neutrophil dysfunction.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Traniello S,Spisani S,Gavioli R,Dovigo L,Baricordi RO,Sensi A,Damiani Gdoi
10.1016/0014-5793(86)81385-0subject
Has Abstractpub_date
1986-08-11 00:00:00pages
47-9issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(86)81385-0journal_volume
204pub_type
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