Abstract:
:An essential component of the chromatin remodeling machinery is NURF (Nucleosome Remodeling Factor), the founding member of the ISWI family of chromatin remodeling complexes. In vertebrates and invertebrates alike, NURF has many important functions in chromatin biology including regulating transcription, establishing boundary elements, and promoting higher order chromatin structure. Since NURF is essential to many aspects of chromatin biology, knowledge of its function is required to fully understand how the genome is regulated. This review will summarize what is currently known of its biological functions, conservation in the most prominent model organisms, biochemical functions as a nucleosome remodeling enzyme, and its possible relevance to human cancer.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Alkhatib SG,Landry JWdoi
10.1016/j.febslet.2011.09.003subject
Has Abstractpub_date
2011-10-20 00:00:00pages
3197-207issue
20eissn
0014-5793issn
1873-3468pii
S0014-5793(11)00667-3journal_volume
585pub_type
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