Abstract:
:Islet amyloid polypeptide (IAPP) is the 37-amino acid peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. Recently, we isolated the human gene encoding IAPP [(1988) FEBS Lett. 239, 227-232]. We now report the nucleotide sequences of a human insulinoma cDNA encoding a complete IAPP precursor, and of the corresponding parts of the IAPP gene. Two exons, which are approx. 5 kb apart in the human genome, encode the 89-amino acid pre-pro-IAPP. At least one additional exon is present further upstream in the IAPP gene. A putative signal sequence at the amino-terminus of the precursor suggests that IAPP is a secreted protein.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mosselman S,Höppener JW,Lips CJ,Jansz HSdoi
10.1016/0014-5793(89)81260-8subject
Has Abstractpub_date
1989-04-10 00:00:00pages
154-8issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(89)81260-8journal_volume
247pub_type
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