The complete islet amyloid polypeptide precursor is encoded by two exons.

Abstract:

:Islet amyloid polypeptide (IAPP) is the 37-amino acid peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. Recently, we isolated the human gene encoding IAPP [(1988) FEBS Lett. 239, 227-232]. We now report the nucleotide sequences of a human insulinoma cDNA encoding a complete IAPP precursor, and of the corresponding parts of the IAPP gene. Two exons, which are approx. 5 kb apart in the human genome, encode the 89-amino acid pre-pro-IAPP. At least one additional exon is present further upstream in the IAPP gene. A putative signal sequence at the amino-terminus of the precursor suggests that IAPP is a secreted protein.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Mosselman S,Höppener JW,Lips CJ,Jansz HS

doi

10.1016/0014-5793(89)81260-8

subject

Has Abstract

pub_date

1989-04-10 00:00:00

pages

154-8

issue

1

eissn

0014-5793

issn

1873-3468

pii

0014-5793(89)81260-8

journal_volume

247

pub_type

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