The complete islet amyloid polypeptide precursor is encoded by two exons.


:Islet amyloid polypeptide (IAPP) is the 37-amino acid peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. Recently, we isolated the human gene encoding IAPP [(1988) FEBS Lett. 239, 227-232]. We now report the nucleotide sequences of a human insulinoma cDNA encoding a complete IAPP precursor, and of the corresponding parts of the IAPP gene. Two exons, which are approx. 5 kb apart in the human genome, encode the 89-amino acid pre-pro-IAPP. At least one additional exon is present further upstream in the IAPP gene. A putative signal sequence at the amino-terminus of the precursor suggests that IAPP is a secreted protein.




FEBS letters


Mosselman S,Höppener JW,Lips CJ,Jansz HS




Has Abstract


1989-04-10 00:00:00














  • MicroRNA-145 regulates osteoblastic differentiation by targeting the transcription factor Cbfb.

    abstract::Osteoblastic differentiation is regulated by various factors, including hormones and transcription factors. Runt-related transcription factor 2 (Runx2) is an essential player in osteoblastogenesis and transactivates its molecular target by creating a protein complex with its hetero-dimeric partner core binding factor ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Fukuda T,Ochi H,Sunamura S,Haiden A,Bando W,Inose H,Okawa A,Asou Y,Takeda S

    更新日期:2015-10-24 00:00:00

  • MECP2 mutation in male patients with non-specific X-linked mental retardation.

    abstract::In contrast to the preponderance of affected males in families with X-linked mental retardation, Rett syndrome (RTT) is a neurological disorder occurring almost exclusively in females. The near complete absence of affected males in RTT families has been explained by the lethal effect of an X-linked gene mutation in he...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Orrico A,Lam C,Galli L,Dotti MT,Hayek G,Tong SF,Poon PM,Zappella M,Federico A,Sorrentino V

    更新日期:2000-09-22 00:00:00

  • Chemical crosslinking studies of the isolated light-harvesting B800-850 complex of Chromatium minutissimum.

    abstract::The spatial relationship of polypeptides comprising the light-harvesting B800-850 complex of Chromatium minutissimum has been studied by means of chemical crosslinking of the isolated complex with cleavable, 1.2 nm-long dithiobis(succinimidyl propionate). The samples were analyzed by different types of electrophoresis...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Moskalenko AA,Toropygina OA

    更新日期:1993-03-29 00:00:00

  • Myocyte stress 1 plays an important role in cellular hypertrophy and protection against apoptosis.

    abstract::Myocyte stress 1 (MS1) is a recently described striated muscle actin-binding protein that is up-regulated in the early stages of pressure overload left ventricular hypertrophy. The aim of this study was to determine whether MS1 induces cellular hypertrophy and protects against apoptosis. Over-expressed MS1 co-localize...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Koekemoer AL,Chong NW,Goodall AH,Samani NJ

    更新日期:2009-09-03 00:00:00

  • Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization.

    abstract::The metastasis suppressor KAI1/CD82 has been implicated in various cellular processes; however, its function in development is not fully understood. Here, we generated and characterized mutants of Tsp66E and Tsp74F, which are Drosophila homologues of KAI1/CD82 and Tspan11, respectively. These mutants exhibited egg elo...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Han SY,Lee M,Hong YK,Hwang S,Choi G,Suh YS,Park SH,Lee S,Lee SH,Chung J,Baek SH,Cho KS

    更新日期:2012-11-16 00:00:00

  • Increased uncoupling protein-2 and -3 gene expressions in skeletal muscle of STZ-induced diabetic rats.

    abstract::Streptozotocin (STZ)-induced diabetic animals are vulnerable to cold stress. Uncoupling proteins (UCPs) play an important role in regulating thermogenesis. We investigated the gene expressions of UCPs in brown adipose tissue (BAT), white adipose tissue (WAT), liver and gastrocnemius muscle of STZ-diabetic rats using N...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kageyama H,Suga A,Kashiba M,Oka J,Osaka T,Kashiwa T,Hirano T,Nemoto K,Namba Y,Ricquier D,Giacobino JP,Inoue S

    更新日期:1998-12-04 00:00:00

  • Inhibition of creatine kinase by S-nitrosoglutathione.

    abstract::The sarcoplasmic reticulum-bound creatine kinase from rabbit skeletal muscle was inhibited by the nitric oxide donor S-nitrosoglutathione (GSNO). This led to a decrease in Ca2+ uptake in sarcoplasmic reticulum vesicles when the transport was driven by ATP generated from phosphocreatine and ADP. In contrast, the Ca 2+ ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Wolosker H,Panizzutti R,Engelender S

    更新日期:1996-09-02 00:00:00

  • Seminalplasmin and caltrin are the same protein.

    abstract::The sequence of seminalplasmin, a basic antimicrobial and transcription-inhibitory protein from bovine seminal plasma, has been determined using an automated sequenator. This sequence is slightly different from that reported earlier by Theil and Scheit [(1983) EMBO J. 2, 1159-1163] and identical with that of caltrin, ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Sitaram N,Kumari VK,Bhargava PM

    更新日期:1986-06-09 00:00:00

  • The constituents of storage granules in the dermal glands of Xenopus laevis. Structure of a basic polypeptide deduced from cloned cDNA.

    abstract::Mature dermal glands of Xenopus laevis contain storage granules with a characteristic ellipsoid shape. A few major proteins are present in these granules, including two with the same amino-terminal sequence and apparent molecular masses of 26 and 28 kDa. Using antibodies against these proteins, positive clones were is...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Berger H,Kreil G

    更新日期:1989-06-05 00:00:00

  • Thermodynamic analysis of the binding of galactose and poly-N-acetyllactosamine derivatives to human galectin-3.

    abstract::Galectin-3, with a wide tissue distribution and marked developmental regulation, provides significant insights into the progression of various disease and developmental stages. Recognized by its specificity for galactose, a detailed characterization of its sugar binding ability has been investigated by isothermal titr...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Bachhawat-Sikder K,Thomas CJ,Surolia A

    更新日期:2001-06-29 00:00:00

  • Analysis of the black-eyed pea trypsin and chymotrypsin inhibitor-alpha-chymotrypsin complex.

    abstract::The black-eyed pea trypsin and chymotrypsin inhibitor (BTCI) is a member of the Bowman-Birk protease inhibitor (BBI) family. The three-dimensional model of the BTCI-chymotrypsin complex was built based on the homology to Bowman-Birk inhibitors with known structures. An extensive theoretical and experimental study of t...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: de Freitas SM,de Mello LV,da Silva MC,Vriend G,Neshich G,Ventura MM

    更新日期:1997-06-09 00:00:00

  • Asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport.

    abstract::The mechanisms involved in bidirectional transport along microtubules remain largely unknown. We explored the collective action of kinesin-2 and dynein motors during transport of melanosomes in Xenopus laevis melanophores. These motors are attached to organelles through accessory proteins establishing a complex molecu...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: De Rossi MC,De Rossi ME,Sued M,Rodríguez D,Bruno L,Levi V

    更新日期:2015-09-14 00:00:00

  • Generation of VV-hemorphin-7 from globin by peritoneal macrophages.

    abstract::Bovine globin has been incubated with mice peritoneal macrophages in order to study its hydrolysis by lysosomal enzymes, among which chiefly cathepsin D. Analysis of resulting peptides, by reversed-phase high-performance liquid chromatography (RP-HPLC), showed the release of a bioactive peptide, VV-hemorphin-7. When a...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Dagouassat N,Garreau I,Sannier F,Zhao Q,Piot JM

    更新日期:1996-03-11 00:00:00

  • Cloning, sequencing and expression of a full-length rabbit fast skeletal troponin-C cDNA.

    abstract::A full-length cDNA coding for troponin-C isolated from an adult rabbit fast skeletal muscle library has been sequenced and expressed in an E. coli host. The amino acid sequence derived from the coding region agrees with the published protein sequence except that the first two residues are reversed. The expressed prote...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Chen Q,Taljanidisz J,Sarkar S,Tao T,Gergely J

    更新日期:1988-02-08 00:00:00

  • The polytopic mitochondrial inner membrane proteins MIM17 and MIM23 operate at the same preprotein import site.

    abstract::Three proteins of the mitochondrial inner membrane are known that are essential for the viability of yeast and seem to be involved in import of preproteins; the integral membrane proteins MIM17 and MIM23 and the peripheral membrane protein MIM44, MIM17 and MIM23 are homologous to each other in their hydrophobic domain...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kübrich M,Keil P,Rassow J,Dekker PJ,Blom J,Meijer M,Pfanner N

    更新日期:1994-08-01 00:00:00

  • The glycan core of GPI-anchored proteins modulates aerolysin binding but is not sufficient: the polypeptide moiety is required for the toxin-receptor interaction.

    abstract::Sensitivity of mammalian cells to the bacterial toxin aerolysin is due to the presence at their surface of glycosylphosphatidyl inositol (GPI)-anchored proteins which act as receptors. Using a panel of mutants that are affected in the GPI biosynthetic pathway and Trypanosoma brucei variant surface glycoproteins, we sh...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Abrami L,Velluz MC,Hong Y,Ohishi K,Mehlert A,Ferguson M,Kinoshita T,Gisou van der Goot F

    更新日期:2002-02-13 00:00:00

  • FixL-like sensor FlbS of Brucella abortus binds haem and is necessary for survival within eukaryotic cells.

    abstract::Replication of Brucella inside eukaryotic cells is essential for pathogenesis, and successful infection requires rapid adaptation to the intracellular milieu. Close relatives of Brucella use the two-component system FixLJ to survive inside the host. We aimed to identify a homologous sensor in Brucella abortus. A predi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Roset MS,Almirón MA

    更新日期:2013-09-17 00:00:00

  • Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle. Phosphorylation of site 5 by glycogen synthase kinase-5 (casein kinase-II) is a prerequisite for phosphorylation of sites 3 by glycogen synthase kinase-3.

    abstract::Glycogen synthase kinase-5 (casein kinase-II) phosphorylates glycogen synthase on a serine termed site 5. This residue is just C-terminal to the 3 serines phosphorylated by glycogen synthase kinase-3, which are critical for the hormonal regulation of glycogen synthase in vivo. Although phosphorylation of site 5 does n...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Picton C,Woodgett J,Hemmings B,Cohen P

    更新日期:1982-12-13 00:00:00

  • Identification and expression of a variant isoform of the levocabastine-sensitive neurotensin receptor in the mouse central nervous system.

    abstract::This work describes the molecular cloning of a variant isoform of the low-affinity levocabastine-sensitive neurotensin receptor isolated from mouse brain. Although the corresponding mRNA encodes for a 282 amino acid protein unable to bind neurotensin after transient transfection in COS-7 cells, this non-functional neu...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Botto JM,Sarret P,Vincent JP,Mazella J

    更新日期:1997-01-03 00:00:00

  • Nature of the pH-induced conformational changes and exposure of the C-terminal region of chromogranin A.

    abstract::Chromogranin A is known to undergo pH induced conformational changes, and the difference in conformation is supposed to be responsible for the difference in Ca2+ binding property. To gain insight regarding the overall structure and the nature of pH-induced conformational changes of chromogranin A, limited trypsin dige...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Yoo SH,Ferretti JA

    更新日期:1993-11-22 00:00:00

  • Cloning of cDNA and genomic DNA for human cytochrome P-45011 beta.

    abstract::A full-length cDNA clone encoding steroid 11 beta-hydroxylase (P-45011 beta) has been isolated from a cDNA library derived from human adrenal tumor. The insert of the clone contains an open reading frame encoding a protein of 503 amino acid residues together with a 4 bp 5'-untranslated region and a 576 bp 3'-untransla...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kawamoto T,Mitsuuchi Y,Toda K,Miyahara K,Yokoyama Y,Nakao K,Hosoda K,Yamamoto Y,Imura H,Shizuta Y

    更新日期:1990-09-03 00:00:00

  • Decreased stability of photosystem I in dgd1 mutant of Arabidopsis thaliana.

    abstract::The dgd1 mutant of Arabidopsis thaliana provides us with a powerful tool for revealing the specific role of digalactosyldiacylglycerol (DGDG) in photosynthesis. Blue-native polyacrylamide gel electrophoresis analysis revealed that photosystem I (PSI) subunits are assembled into a PSI complex, and that a PSI subcomplex...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Guo J,Zhang Z,Bi Y,Yang W,Xu Y,Zhang L

    更新日期:2005-07-04 00:00:00

  • Mechanisms of tetraethylammonium ion block in the KcsA potassium channel.

    abstract::We report results from automated docking and microscopic molecular dynamics simulations of the tetraethylammonium (TEA) complexes with KcsA. Binding modes and energies for TEA binding at the external and internal sides of the channel pore are examined utilising the linear interaction energy method. Effects of the chan...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Luzhkov VB,Aqvist J

    更新日期:2001-04-27 00:00:00

  • Mechano-chemical effects of Ca(2+) in cross-linked troponin-C films.

    abstract::Changes in troponin C (TnC) conformation upon Ca(2+) binding forms the basis for regulatory and structural functions of TnC molecules. In the present study, Ca(2+)-induced conformational changes in TnC were observed by mechanical measurements. TnC films were prepared by drying or electrospraying TnC solutions, cross-l...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Bukatina AE,Morozov VN,Gusev NB,Sieck GC

    更新日期:2002-07-31 00:00:00

  • No evidence for a forced-unfolding mechanism during ATP/GroES binding to substrate-bound GroEL: no observable protection of metastable Rubisco intermediate or GroEL-bound Rubisco from tritium exchange.

    abstract::In tritium-hydrogen exchange experiments, the large GroEL substrate Rubisco was unfolded and exchanged in urea/acid/tritiated water, then diluted into either protic buffer or protic buffer containing GroEL. The respective Rubisco metastable folding intermediate or Rubisco-GroEL binary complex was then separated from r...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Park ES,Fenton WA,Horwich AL

    更新日期:2005-02-14 00:00:00

  • Identification and structural characterization of a mannose-6-phosphate containing oligomannosidic N-glycan from human erythropoietin secreted by recombinant BHK-21 cells.

    abstract::A sialidase resistant mono-charged N-glycan was isolated from glycosylation site I (Asn-24) of recombinant human erythropoietin expressed from baby hamster kidney (BHK-21) cells and constituted approximately 2-4% of the oligosaccharide material at this glycosylation site. Mass spectrometry and both 1- and 2-dimensiona...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Nimtz M,Wray V,Rüdiger A,Conradt HS

    更新日期:1995-05-29 00:00:00

  • Involvement of SigT and RstA in the differentiation of Streptomyces coelicolor.

    abstract::SigT is an ECF sigma factor in Streptomyces coelicolor. sigT and its putative anti-sigma factor gene rstA are located in one putative operon, and SigT could physically interact with RstA. Deletion of sigT or rstA caused accelerated morphological development and enhanced production of antibiotics, concomitant with over...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Mao XM,Zhou Z,Cheng LY,Hou XP,Guan WJ,Li YQ

    更新日期:2009-10-06 00:00:00

  • Human Z alpha 1-antitrypsin accumulates intracellularly and stimulates lysosomal activity when synthesised in the Xenopus oocyte.

    abstract::Microinjection of human liver mRNA from a patient homozygous for alpha 1-antitrypsin deficiency (PiZZ) into Xenopus oocytes led to a 2--10-fold increase in lysosomal activity. Stimulation of lysosomal activity was not observed when mRNA from a normal human liver (alpha 1-antitrypsin PiMM), or water was injected into t...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Bathurst IC,Errington DM,Foreman RC,Judah JD,Carrell RW

    更新日期:1985-04-22 00:00:00

  • Export of Thermus thermophilus alkaline phosphatase via the twin-arginine translocation pathway in Escherichia coli.

    abstract::The bacterial twin-arginine translocation (Tat) pathway is distinct from the Sec system by its remarkable capacity to export folded enzymes. To address the question whether the two systems are capable of translocating homologous enzymes catalyzing the same reaction, we cloned the tap gene encoding Thermus thermophilus...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Angelini S,Moreno R,Gouffi K,Santini C,Yamagishi A,Berenguer J,Wu L

    更新日期:2001-10-05 00:00:00

  • Beta-oxidation of polyunsaturated fatty acids in peroxisomes. Subcellular distribution of delta 3,delta 2-enoyl-CoA isomerase activity in rat liver.

    abstract::The metabolism of the double bonds at the delta 3 position in fatty acids was studied in rat liver. Infusion of delta 3-trans-dodecenoic acid into isolated perfused liver and subcellular fractionation studies showed the presence of both peroxisomal and mitochondrial delta 3,delta 2-enoyl-CoA isomerase activity (EC 5.3...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kärki T,Hakkola E,Hassinen IE,Hiltunen JK

    更新日期:1987-05-11 00:00:00