Abstract:
:Liposomes containing acyl chains incorporating azobenzene chromophores have been investigated as potential 'caging' agents for fast solute release. On photolysis, trapped marker dye can be released from gel-phase liposomes within milliseconds. Solute release is markedly sensitive to the presence of cholesterol in the bilayer. Phospholipids bearing one saturated acyl chain and an azobenzene-substituted chain are ineffective as sensitisers unless cholesterol is present, while doubly substituted phospholipids sensitise release in its absence. Cholesterol markedly affects the temperature profile of solute release depending on the host phospholipid chain length. Solute release is not seen for lipid hosts with unsaturated acyl chains.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bisby RH,Mead C,Morgan CGdoi
10.1016/s0014-5793(99)01612-9keywords:
subject
Has Abstractpub_date
1999-12-10 00:00:00pages
165-8issue
1-2eissn
0014-5793issn
1873-3468pii
S0014-5793(99)01612-9journal_volume
463pub_type
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