Abstract:
:A wide variety of phospholipase A2 inhibitors blocks intra-Golgi protein transport reconstituted in a cell-free system. Phospholipase A2 activity detectable under the protein transport assay conditions is actually inhibited by the inhibitors. There is a good correlation between the inhibition of protein transport and that of phospholipase A2 activity. Prolactin secretion from GH3 cells is also blocked by a membrane-permeable phospholipase A2 inhibitor, suggesting the physiological relevance to inhibition of protein transport in vitro by phospholipase A2 inhibitors.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tagaya M,Henomatsu N,Yoshimori T,Yamamoto A,Tashiro Y,Fukui Tdoi
10.1016/0014-5793(93)81393-esubject
Has Abstractpub_date
1993-06-14 00:00:00pages
201-4issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(93)81393-Ejournal_volume
324pub_type
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