Abstract:
:Lipid analyses were carried out on transplantable murine Friend leukemia cell tumors, 6 h after intratumoral administration of tumor necrosis factor-alpha (TNF). The levels of the major phospholipid classes were uniformly decreased to about 70% of control values; free fatty acids were increased to about 170%; diacylglycerol was decreased to about 50% and triacylglycerol, the main lipid component, was not significantly altered. These results analysed in the light of concomitant alterations in the levels of phospholipid precursors and catabolites (determined in previous 31P NMR studies) and histological modifications demonstrated that at early stages of TNF-induced inhibition of tumor growth (a) phospholipid catabolism was significantly enhanced; (b) morphological changes were apparently correlated with alterations in the levels of phosphatidylcholine and its catabolic products.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bravo E,Carpinelli G,Proietti E,Belardelli F,Cantafora A,Podo Fdoi
10.1016/0014-5793(90)80108-usubject
Has Abstractpub_date
1990-01-29 00:00:00pages
220-4issue
2eissn
0014-5793issn
1873-3468journal_volume
260pub_type
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