Abstract:
:Tomato Cf-9, a receptor-like protein (RLP), confers resistance to races of the fungal pathogen Cladosporium fulvum that express the Avr9 avirulence gene. CITRX (Cf-9-interacting thioredoxin) was previously identified in a yeast two-hybrid screen as a protein interacting with the cytoplasmic domain of Cf-9 and shown to be a negative regulator of the cell death induced after Cf-9/Avr9 interaction. ACIK1 is a Ser/Thr protein kinase that is specifically required for the Cf-9 and Cf-4 dependent defence response in tomato. In this paper we present data suggesting that CITRX may act as an adaptor recruiting the ACIK1 kinase to the cytoplasmic domain of Cf-9 upon elicitation with the Avr9 peptide. Interestingly, the catalytic activities of both CITRX and ACIK1 are not required for their interaction.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nekrasov V,Ludwig AA,Jones JDdoi
10.1016/j.febslet.2006.06.077subject
Has Abstractpub_date
2006-07-24 00:00:00pages
4236-41issue
17eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00794-0journal_volume
580pub_type
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