Abstract:
:Effects of sulfatide and its precursor galactosylceramide (gal-cer) on the kinetics of production of cytokines were studied. In human mononuclear leucocytes, gal-cer but not sulfatide induced significantly increased amounts of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF) mRNA. In phytohemagglutinin-stimulated cultures, gal-cer increased the levels of IL-1beta and IL-6 mRNA and secreted IL-1beta and IL-6, while sulfatide decreased the amounts of IL-6 mRNA and secreted IL-6. Gal-cer also increased TNF secretion. In lipopolysaccharide-stimulated cells, sulfatide but not gal-cer decreased the secretion of IL-1beta and IL-10, a potent suppressor of production of many cytokines. Thus, sulfatide and gal-cer affect cytokine production differently, most likely at the level of gene expression. This may have implications in diseases where inflammatory cytokines play a pathogenic role.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bovin LF,Fredman P,Månsson JE,Buschard K,Bendtzen Kdoi
10.1016/s0014-5793(99)00908-4keywords:
subject
Has Abstractpub_date
1999-07-23 00:00:00pages
339-43issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(99)00908-4journal_volume
455pub_type
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