Abstract:
:Eucaryotic DNA is punctuated by many A+T-rich segments that we named A+T-rich linkers. Two types of these A+T-rich linkers can be distinguished: (i) isolated A+T-rich linkers, and (ii) A+T-rich linkers crowded in clusters. We have analysed the distribution of A+T-rich linker across the alpha- and beta-globin gene domain in Xenopus laevis and human genomes using isodenaturation and electron microscopy. Comparison of our data with those previously obtained for the avian globin genes leads us to conclude that genes can be harboured indifferently in either domain. A correlation is established between the presence of A+T-rich linker inside introns and flanking regions and the A+T content of the coding sequence. For the coding sequence, a high A+T content is strongly correlated with high A+T content in the codon's third position and weakly in the first position.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Moreau J,Scherrer Kdoi
10.1016/0014-5793(87)80342-3subject
Has Abstractpub_date
1987-08-31 00:00:00pages
3-10issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(87)80342-3journal_volume
221pub_type
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