Abstract:
:We show that some arbitrarily chosen DNA sequences have the ability to influence the positioning of RecA monomers in RecA-DNA complexes. The preferential phase of binding of RecA monomers is shown to depend on the DNA sequence and its nucleotide composition. A simple rearrangement of bases in a limited DNA stretch influences the phasing of RecA monomers. On the other hand, that some features of DNA sequences interfere with the phasing on specific DNA sites demonstrates the existence of mechanisms for both positive and negative regulation of phasing on natural DNAs. The possible role of phasing of RecA monomers on DNA is discussed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Volodin AA,Smirnova EA,Bocharova TN,Camerini-Otero RDdoi
10.1016/s0014-5793(03)00572-6keywords:
subject
Has Abstractpub_date
2003-07-10 00:00:00pages
203-8issue
2-3eissn
0014-5793issn
1873-3468pii
S0014579303005726journal_volume
546pub_type
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