Abstract:
:It is increasingly clear that microRNAs play a crucial role in tumorigenesis. Recently, emerging evidence suggested that miR-26a is aberrantly expressed in tumor tissues. In our study, frequent down-regulation of miR-26a was observed in 10 human bladder cancer tissues. Forced expression of miR-26a in the bladder cancer cell line T24 inhibited cell proliferation and impaired cell motility. High mobility group AT-hook 1 (HMGA1), a gene that modulates cell cycle transition and cell motility, was verified as a novel target of miR-26a in bladder cancer. These findings indicate an important role for miR-26a in the molecular etiology of bladder cancer and implicate the potential application of miR-26a in bladder cancer therapy.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Lin Y,Chen H,Hu Z,Mao Y,Xu X,Zhu Y,Xu X,Wu J,Li S,Mao Q,Zheng X,Xie Ldoi
10.1016/j.febslet.2013.06.021subject
Has Abstractpub_date
2013-08-02 00:00:00pages
2467-73issue
15eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00468-7journal_volume
587pub_type
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