Vitronectin-dependent invasion of epithelial cells by Neisseria gonorrhoeae involves alpha(v) integrin receptors.

Abstract:

:Binding of vitronectin (VN) to Neisseria gonorrhoeae expressing the heparan sulfate proteoglycan (HSPG) specific Opa50 protein was recently shown to trigger bacterial internalization into distinct epithelial cell lines. We have investigated the role of VN-binding integrin receptors and protein kinase C (PKC) in VN-triggered bacterial uptake. Blocking integrin function by RGDS peptides or by antibodies specific to alpha(v)beta5 or alpha(v)beta3 resulted in an abrogation of VN-triggered bacterial internalization. Moreover, inhibitors of PKC were found to block VN-triggered uptake. The essential role of alpha(v) integrins and the presumable involvement of PKC in VN-triggered gonococcal uptake are discussed.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Dehio M,Gómez-Duarte OG,Dehio C,Meyer TF

doi

10.1016/s0014-5793(98)00144-6

subject

Has Abstract

pub_date

1998-03-06 00:00:00

pages

84-8

issue

1-2

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(98)00144-6

journal_volume

424

pub_type

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