Abstract:
:Histone H1(0) is found in tissues with little or no cellular proliferation and has been shown to accumulate during cellular terminal differentiation. Two subtypes of H1(0), H1 a and H1 b, are present in any tissue where the protein has been detected. We report here the first evidence of an age-dependent change in the proportions of H1 subtypes. In rat cerebral cortex neurons the proportion of H1 a rises from 44% of total H1 at birth to about 80% at day 300. These results show that terminally differentiated neurons synthesize and exchange H1 at a significant rate.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Piña B,Suau Pdoi
10.1016/0014-5793(87)81328-5subject
Has Abstractpub_date
1987-01-05 00:00:00pages
161-4issue
2eissn
0014-5793issn
1873-3468journal_volume
210pub_type
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