Abstract:
:Creutzfeldt-Jakob disease is a slow, infectious, progressive neurological disorder which results in human dementia. Synaptic membranes from various brain regions of guinea pigs infected with Creutzfeldt-Jakob disease show increased guanyl nucleotide- or 5-hydroxytryptamine-mediated activation of adenylate cyclase. This increased enzyme activity appears due, primarily, to facilitated 'coupling' between the GTP-binding protein which stimulates adenylate cyclase (GNs) and the catalytic moiety of that enzyme rather than increased sensitivity to 5-hydroxytryptamine. It is possible that this phenomenon is due to direct effects of the Creutzfeldt-Jakob infectious agent, or a pathological product resulting from that agent, upon synaptic membrane adenylate cyclase.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rasenick MM,Valley S,Manuelidis EE,Manuelidis Ldoi
10.1016/0014-5793(86)81205-4subject
Has Abstractpub_date
1986-03-17 00:00:00pages
164-8issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(86)81205-4journal_volume
198pub_type
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