Abstract:
:The conformation of the glycine-rich loop of adenylate kinase is described in detail. It forms a giant anion hole for a sulfate ion, which presumably mimicks a nucleotide phosphoryl group. This loop had been called flexible, because at pH values of 6 or below it is displaced in the crystal. In the region of this loop the adenylate kinases are probably homologous to the p21 proteins. Is is known that a mutation in this loop at residue 12 of p21 causes cell transformation and therefore cancer. Other potentially homologous proteins are indicated.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Dreusicke D,Schulz GEdoi
10.1016/0014-5793(86)81037-7subject
Has Abstractpub_date
1986-11-24 00:00:00pages
301-4issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(86)81037-7journal_volume
208pub_type
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